Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR2 | P34972 | 10/20 | 0.65 |
| ▸ | CNR1 | P21554 | 9/20 | 0.65 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.38 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.37 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.36 |
| ▸ | FAAH | O00519 | 1/20 | 0.36 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.36 |
| ▸ | LDHA | P00338 | 1/20 | 0.36 |
| ▸ | GLRA1 | P23415 | 1/20 | 0.36 |
| ▸ | GPR183 | P32249 | 1/20 | 0.36 |
| ▸ | DRD3 | P35462 | 1/20 | 0.36 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.36 |
| ▸ | GPR18 | Q14330 | 1/20 | 0.36 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.36 |
| ▸ | ABHD12 | Q8N2K0 | 1/20 | 0.36 |
| ▸ | ABHD6 | Q9BV23 | 1/20 | 0.36 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8828977 | 0.81 | CNR2 (0.65) | CNR2CNR1MEN1GAAKMT2A | |
| SCHEMBL31103617 | 0.79 | CNR2 (1.00) | CNR2CNR1MEN1GAAKMT2A | |
| SCHEMBL4537590 | 0.79 | CNR2 (1.00) | CNR2CNR1MEN1GAAKMT2A | |
| SCHEMBL5090381 | 0.79 | CNR2 (1.00) | CNR2CNR1MEN1GAAKMT2A | |
| SCHEMBL1114914 | 0.78 | CNR2 (0.98) | CNR2CNR1MEN1GAAKMT2A | |
| SCHEMBL11599749 | 0.76 | CNR1 (0.73) | CNR2CNR1MEN1GAAKMT2A | |
| SCHEMBL16124349 | 0.75 | CNR2 (0.94) | CNR2CNR1MEN1GAAKMT2A | |
| SCHEMBL11602695 | 0.74 | CNR2 (0.58) | CNR2CNR1OPRM1ACE2TRPV1 | |
| SCHEMBL11601783 | 0.73 | CNR2 (0.57) | CNR2CNR1OPRM1ACE2TRPV1 | |
| SCHEMBL11602544 | 0.73 | CNR2 (0.57) | CNR2CNR1OPRM1ACE2TRPV1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5605906-A | LOWERING OCULAR PRESSURE; ANTIINFLAMMATORY AGENT; IMMUNOSUPPRESSIVE; ANALGESICS | MERCK FROSST CANADA, INC. (CA) | 1997-02-25 | — | — | US | disclosed |
| US-4405626-A | TRANQUILIZERS, HYPOTENSIVE AGENTS; DIURETICS; VISION DEFECTS | PFIZER INC. (US) | 1983-09-20 | — | — | US | disclosed |
| US-4400385-A | TRANQUILIZERS, HYPOTENSIVE AGENTS; DIURETICS; VISION DEFECTS | PFIZER INC. (US) | 1983-08-23 | — | — | US | disclosed |
| US-4380542-A | ANALGESICS, TRANQUILIZERS | PFIZER (US) | 1983-04-19 | — | — | US | disclosed |
| EP-0009386-B1 | 2,10-DISUBSTITUTED DIBENZO(B,D)PYRANS AND BENZO(C)QUINOLINES AND PHARMACEUTICAL COMPOSITIONS THEREOF | PFIZER INC. (US) | 1982-11-17 | — | — | EP | disclosed |
| US-4351833-A | 9-Amino-1-hydroxyoctahydrobenzo[c]quinolines and derivatives thereof as analgesics and anti-emetics | PFIZER INC. (US) | 1982-09-28 | — | — | US | disclosed |
| US-4340737-A | CNS AGENTS, HYPOTENSIVES, DIURETICS AND AGENTS FOR TREATMENT OF GLAUCOMA | PFIZER INC. (US) | 1982-07-20 | — | — | US | disclosed |
| EP-0045171-A2 | 9-Amino-1-hydroxyoctahydrobenzo(c)quinolines and derivatives thereof | PFIZER INC. (US) | 1982-02-03 | — | — | EP | disclosed |
| US-4309545-A | ANALGESICS, TRANQUILIZERS, ANTIEMETICS, DIURETICS, ANTICONVULSANTS, ANTIDIARRHEAL, ANTITUSSIVES AND IN THE TREATMENT OF GLAUCOMA | PFIZER INC. (US) | 1982-01-05 | — | — | US | disclosed |
| US-4260764-A | ANALGESICS, TRANQUILIZERS | PFIZER INC. (US) | 1981-04-07 | — | — | US | disclosed |
| US-4206225-A | ANALGESICS | PFIZER INC. (US) | 1980-06-03 | — | — | US | disclosed |