Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYSLTR1 | Q9Y271 | 8/20 | 0.61 |
| ▸ | CYSLTR2 | Q9NS75 | 7/20 | 0.61 |
| ▸ | PTGER4 | P35408 | 2/20 | 0.55 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.39 |
| ▸ | BCL2L1 | Q07817 | 4/20 | 0.38 |
| ▸ | MCL1 | Q07820 | 4/20 | 0.38 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8829460 | 1.00 | CYSLTR1 (0.61) | CYSLTR1CYSLTR2PTGER4HDAC6BCL2L1 | |
| SCHEMBL8829342 | 0.89 | CYSLTR1 (0.79) | CYSLTR1CYSLTR2PTGER4 | |
| SCHEMBL8829347 | 0.89 | CYSLTR1 (0.79) | CYSLTR1CYSLTR2PTGER4 | |
| SCHEMBL8829386 | 0.89 | CYSLTR1 (0.79) | CYSLTR1CYSLTR2PTGER4 | |
| SCHEMBL8829406 | 0.88 | CYSLTR1 (0.69) | CYSLTR1CYSLTR2PTGER4HDAC6ALOX5 | |
| SCHEMBL8829393 | 0.88 | CYSLTR1 (0.69) | CYSLTR1CYSLTR2PTGER4HDAC6ALOX5 | |
| SCHEMBL8829397 | 0.88 | CYSLTR1 (0.69) | CYSLTR1CYSLTR2PTGER4HDAC6ALOX5 | |
| SCHEMBL9146513 | 0.85 | CYSLTR1 (0.60) | CYSLTR1CYSLTR2PTGER4ALOX5 | |
| SCHEMBL8829396 | 0.85 | CYSLTR1 (0.60) | CYSLTR1CYSLTR2PTGER4ALOX5 | |
| SCHEMBL8829399 | 0.85 | CYSLTR1 (0.60) | CYSLTR1CYSLTR2PTGER4ALOX5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0404440-B1 | Substituted sulfonamides and related compounds in the treatment of asthma, arthritis, and related diseases | PFIZER (US) | 1997-11-05 | — | — | EP | disclosed |
| US-5384318-A | Substituted sulfonamides and related compounds in the treatment of asthma, arthritis and related diseases | PFIZER INC. (US) | 1995-01-24 | — | — | US | disclosed |
| EP-0404440-A2 | Substituted sulfonamides and related compounds in the treatment of asthma, arthritis, and related diseases | PFIZER INC. (US) | 1990-12-27 | — | — | EP | disclosed |
| WO-1990015801-A1 | SUBSTITUTED SULFONAMIDES AND RELATED COMPOUNDS IN THE TREATMENT OF ASTHMA, ARTHRITIS AND RELATED DISEASES | PFIZER INC. (US) | 1990-12-27 | — | — | WO | disclosed |