Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1C3 | P42330 | 3/20 | 0.60 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.54 |
| ▸ | ESR1 | P03372 | 2/20 | 0.53 |
| ▸ | ESR2 | Q92731 | 2/20 | 0.53 |
| ▸ | ESRRG | P62508 | 1/20 | 0.53 |
| ▸ | AKR1C1 | Q04828 | 2/20 | 0.53 |
| ▸ | MEN1 | O00255 | 3/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | DEGS1 | O15121 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | DHODH | Q02127 | 1/20 | 0.48 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8830705 | 1.00 | AKR1C3 (0.60) | AKR1C3PTGS2ESR1ESR2ESRRG | |
| SCHEMBL10362481 | 0.91 | AKR1C1 (0.65) | AKR1C3PTGS2AKR1C1MEN1KMT2A | |
| SCHEMBL11671064 | 0.89 | AKR1C3 (0.72) | AKR1C3AKR1C1MEN1KMT2AALDH1A1 | |
| SCHEMBL11576396 | 0.89 | AKR1C3 (0.72) | AKR1C3AKR1C1MEN1KMT2AALDH1A1 | |
| SCHEMBL8830409 | 0.87 | NQO2 (0.63) | AKR1C3ESR1ESR2ESRRGMEN1 | |
| SCHEMBL8830412 | 0.87 | NQO2 (0.63) | AKR1C3ESR1ESR2ESRRGMEN1 | |
| SCHEMBL11579533 | 0.84 | AKR1C3 (0.67) | AKR1C3PTGS2AKR1C1MEN1KMT2A | |
| SCHEMBL13092046 | 0.82 | AKR1C1 (0.78) | AKR1C3PTGS2ESR1AKR1C1MEN1 | |
| SCHEMBL14591173 | 0.82 | AKR1C1 (0.78) | AKR1C3PTGS2ESR1AKR1C1MEN1 | |
| SCHEMBL1981785 | 0.82 | AKR1C1 (0.78) | AKR1C3PTGS2ESR1AKR1C1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5627207-A | CANCER | FARMITALIA CARLO ERBA S R L (IT) | 1997-05-06 | — | — | US | disclosed |
| US-5488057-A | ENZYME INHIBITORS AND ANTICARCINOGENIC AGENTS | FARMITALIA CARLO ERBA S.R.L. (IT) | 1996-01-30 | — | — | US | disclosed |
| EP-0662473-A1 | 2-Oxindole derivatives as tyrosine kinase inhibitors | PHARMACIA S.p.A. (IT) | 1995-07-12 | — | — | EP | disclosed |
| US-5374652-A | Substituted naphthylmethylene- or tetrahydronaphthylmethylene-derivatives of 2-oxoindole | FARMITALIA CARLO ERBA S R L (IT) | 1994-12-20 | — | — | US | disclosed |
| EP-0470221-A1 | NEW ARYL- AND HETEROARYLETHENYLENE DERIVATIVES AND PROCESS FOR THEIR PREPARATION. | ERBA CARLO SPA (IT) | 1992-02-12 | — | — | EP | disclosed |
| WO-1991013055-A2 | NEW ARYL- AND HETEROARYLETHENYLENE DERIVATIVES AND PROCESS FOR THEIR PREPARATION | FARMITALIA CARLO ERBA S.R.L. (IT) | 1991-09-05 | — | — | WO | disclosed |