⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10597332 | 0.71 | — | — | |
| SCHEMBL979403 | 0.71 | — | — | |
| SCHEMBL11663026 | 0.68 | — | — | |
| SCHEMBL11226399 | 0.67 | — | — | |
| SCHEMBL2830238 | 0.67 | — | — | |
| SCHEMBL19021935 | 0.67 | — | — | |
| SCHEMBL7401726 | 0.65 | AKR1B1 (0.31) | — | |
| SCHEMBL10955785 | 0.65 | — | — | |
| SCHEMBL14155598 | 0.64 | — | — | |
| SCHEMBL29689731 | 0.62 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5677329-A | ANTAGONIST TO EPIDERMAL GROWTH FACTOR | RHONE-POULENC RORER PHARMACEUTICALS, INC. (US) | 1997-10-14 | — | — | US | disclosed |
| US-5597837-A | Method and composition for treating psoriasis with styryl-substituted pyridyl compounds | Rh one-Poulenc Rorer Pharmaceuticals Inc. (US) | 1997-01-28 | — | — | US | disclosed |
| EP-0525109-A4 | STYRYL-SUBSTITUTED MONOCYCLIC AND BICYCLIC HETEROARYL COMPOUNDS WHICH INHIBIT EGF RECEPTOR TYROSINE KINASE | — | 1993-06-30 | — | — | EP | disclosed |
| EP-0525109-A1 | STYRYL-SUBSTITUTED MONOCYCLIC AND BICYCLIC HETEROARYL COMPOUNDS WHICH INHIBIT EGF RECEPTOR TYROSINE KINASE | RHONE-POULENC RORER INTERNATIONAL (HOLDINGS) INC. (US) | 1993-02-03 | — | — | EP | disclosed |