Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 2/20 | 1.00 |
| ▸ | DRD2 | P14416 | 3/20 | 0.39 |
| ▸ | HTR2A | P28223 | 2/20 | 0.39 |
| ▸ | KCNJ1 | P48048 | 1/20 | 0.39 |
| ▸ | ABCC9 | O60706 | 2/20 | 0.36 |
| ▸ | ABCC8 | Q09428 | 2/20 | 0.36 |
| ▸ | KCNJ11 | Q14654 | 2/20 | 0.36 |
| ▸ | KCNJ8 | Q15842 | 2/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | DRD3 | P35462 | 2/20 | 0.36 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.35 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.34 |
| ▸ | HTR2C | P28335 | 1/20 | 0.34 |
| ▸ | HTR6 | P50406 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8831776 | 1.00 | KCNH2 (1.00) | KCNH2DRD2HTR2AKCNJ1ABCC9 | |
| SCHEMBL30283229 | 1.00 | KCNH2 (1.00) | KCNH2DRD2HTR2AKCNJ1ABCC9 | |
| SCHEMBL4706649 | 1.00 | KCNH2 (1.00) | KCNH2DRD2HTR2AKCNJ1ABCC9 | |
| SCHEMBL6368599 | 1.00 | KCNH2 (1.00) | KCNH2DRD2HTR2AKCNJ1ABCC9 | |
| SCHEMBL8832186 | 1.00 | KCNH2 (1.00) | KCNH2DRD2HTR2AKCNJ1ABCC9 | |
| Hydrochloric Acid SCHEMBL8565783 | 0.99 | KCNH2 (0.98) | KCNH2DRD2HTR2AKCNJ1ABCC9 | |
| Hydrochloric Acid SCHEMBL8832243 | 0.99 | KCNH2 (0.98) | KCNH2DRD2HTR2AKCNJ1ABCC9 | |
| Hydrochloric Acid SCHEMBL8832001 | 0.91 | KCNH2 (0.83) | KCNH2DRD2HTR2AHRH3 | |
| SCHEMBL8832002 | 0.91 | KCNH2 (0.83) | KCNH2DRD2HTR2AKCNJ1DRD3 | |
| SCHEMBL7383236 | 0.91 | KCNH2 (0.83) | KCNH2DRD2HTR2AKCNJ1DRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5698566-A | ANTIARRHYTHMIA AGENTS, CARDIOTONIC AGENTS | MERCK & CO., INC. (US) | 1997-12-16 | — | — | US | disclosed |