Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.64 |
| ▸ | MAPT | P10636 | 3/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.43 |
| ▸ | PPARG | P37231 | 1/20 | 0.43 |
| ▸ | PPARA | Q07869 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31232896 | 0.78 | POLB (1.00) | POLBMAPTLMNAALDH1A1MAPK1 | |
| SCHEMBL6756690 | 0.78 | POLB (1.00) | POLBMAPTLMNAALDH1A1MAPK1 | |
| SCHEMBL9171290 | 0.76 | SRC (0.50) | LMNAKDM4ERIPK1 | |
| SCHEMBL1542688 | 0.76 | POLB (0.66) | POLBMAPTLMNAALDH1A1MAPK1 | |
| SCHEMBL8832114 | 0.76 | POLB (0.60) | POLBMAPTLMNAALDH1A1MAPK1 | |
| SCHEMBL28002410 | 0.76 | MAPK1 (0.64) | POLBMAPTLMNAALDH1A1MAPK1 | |
| SCHEMBL2281034 | 0.74 | POLB (0.68) | POLBMAPTLMNAALDH1A1MAPK1 | |
| SCHEMBL7160912 | 0.74 | POLB (0.68) | POLBMAPTLMNAALDH1A1MAPK1 | |
| SCHEMBL11369813 | 0.74 | POLB (0.58) | POLBMAPTLMNAALDH1A1MAPK1 | |
| SCHEMBL8832180 | 0.74 | POLB (0.50) | POLBMAPTLMNAALDH1A1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5412141-A | Bisphosphonic acid derivatives as anti-arthritic agents | THE UPJOHN COMPANY (US) | 1995-05-02 | — | — | US | claimed |
| EP-0544812-B1 | BISPHOSPHONIC ACID DERIVATIVES AS ANTI-ARTHRITIC AGENTS | UPJOHN CO (US) | 1995-04-05 | — | — | EP | claimed |
| EP-0544812-A1 | BISPHOSPHONIC ACID DERIVATIVES AS ANTI-ARTHRITIC AGENTS. | UPJOHN CO (US) | 1993-06-09 | — | — | EP | claimed |
| WO-1992003451-A1 | BISPHOSPHONIC ACID DERIVATIVES AS ANTI-ARTHRITIC AGENTS | THE UPJOHN COMPANY (US) | 1992-03-05 | — | — | WO | claimed |
| US-5602115-A | Bisphosphonic acid derivatives as anti-arthritic agents | THE UPJOHN COMPANY (US) | 1997-02-11 | — | — | US | disclosed |