Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 11/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | ELANE | P08246 | 2/20 | 0.32 |
| ▸ | F2 | P00734 | 1/20 | 0.32 |
| ▸ | PLAU | P00749 | 1/20 | 0.32 |
| ▸ | JMJD6 | Q6NYC1 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
| ▸ | POLB | P06746 | 2/20 | 0.31 |
| ▸ | USP2 | O75604 | 1/20 | 0.31 |
| ▸ | PKM | P14618 | 1/20 | 0.31 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | SIRT2 | Q8IXJ6 | 2/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL876187 | 0.93 | LRRK2 (0.46) | LRRK2MAPK1ALDH1A1SMN1; SMN2SIRT2 | |
| SCHEMBL875083 | 0.91 | LRRK2 (0.47) | LRRK2MAPK1ALDH1A1SIRT2 | |
| SCHEMBL875073 | 0.89 | LRRK2 (0.47) | LRRK2MAPK1SIRT2 | |
| SCHEMBL10225769 | 0.88 | LRRK2 (0.46) | LRRK2MAPK1ALDH1A1SMN1; SMN2SIRT2 | |
| SCHEMBL878421 | 0.85 | LRRK2 (0.48) | LRRK2MAPK1ALDH1A1 | |
| SCHEMBL13966397 | 0.84 | LRRK2 (0.50) | LRRK2ELANEJMJD6TP53SMN1; SMN2 | |
| SCHEMBL10225768 | 0.83 | LRRK2 (0.47) | LRRK2MAPK1SIRT2 | |
| SCHEMBL874913 | 0.81 | LRRK2 (0.54) | LRRK2 | |
| SCHEMBL10224625 | 0.78 | LRRK2 (0.54) | LRRK2 | |
| SCHEMBL10225766 | 0.77 | LRRK2 (0.39) | LRRK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012038743-A1 | PYRAZOLOPYRIDINES AS INHIBITORS OF THE KINASE LRRK2 | MEDICAL RESEARCH COUNCIL TECHNOLOGY (GB) | 2012-03-29 | — | — | WO | disclosed |