Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 3/20 | 0.62 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.62 |
| ▸ | GLA | P06280 | 1/20 | 0.62 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.56 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.52 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.52 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.52 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 2/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | HPGD | P15428 | 2/20 | 0.51 |
| ▸ | MAPT | P10636 | 3/20 | 0.51 |
| ▸ | NPC1 | O15118 | 2/20 | 0.51 |
| ▸ | RAB9A | P51151 | 2/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | AHR | P35869 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8834122 | 0.91 | AKR1C3 (0.58) | GAAKDM4EGLAHSD17B10ALDH1A1 | |
| SCHEMBL8834053 | 0.88 | AKR1C3 (0.63) | GAAKDM4EGLAHSD17B10ALDH1A1 | |
| SCHEMBL1963476 | 0.83 | MAPT (0.54) | GAAKDM4EGLAHSD17B10ALDH1A1 | |
| SCHEMBL8833711 | 0.83 | TP53 (0.55) | GAAKDM4EGLAHSD17B10ALDH1A1 | |
| SCHEMBL5846672 | 0.81 | TP53 (0.56) | GAAKDM4EGLAHSD17B10ALDH1A1 | |
| SCHEMBL8834506 | 0.80 | AKR1C3 (0.67) | GAAKDM4EALDH1A1AKR1C3AKR1C2 | |
| Methyl 2,4-Dimethoxybenzoate SCHEMBL645462 | 0.80 | KMT2A (0.64) | GAAKDM4EGLAHSD17B10ALDH1A1 | |
| SCHEMBL8834580 | 0.79 | AKR1C3 (0.62) | GAAKDM4EHSD17B10CYP1A2AKR1C3 | |
| SCHEMBL8834135 | 0.77 | AKR1C3 (0.55) | GAAKDM4EHSD17B10ALDH1A1AKR1C3 | |
| Methyl 2,5-Dimethoxybenzoate SCHEMBL2091289 | 0.76 | MAPT (0.66) | GAAKDM4EGLAHSD17B10ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5663336-A | IMIDATION OF DIAMINOPHTHALIC ACID TO FORM KINASE INHIBITORS AS ANTITUMOR AGENTS | CIBA-GEIGY CORPORATION (US) | 1997-09-02 | — | — | US | disclosed |
| US-5491144-A | KINASE INHIBITORS, ANTITUMOR AGENTS | CIBA-GEIGY CORPORATION (US) | 1996-02-13 | — | — | US | disclosed |