SCHEMBL8834091

SCHEMBL8834091

CCCCCC1CCC(c2ccc(CCc3ccc(-c4ccc(OC(F)(F)C(F)C(F)(F)F)c(F)c4)cc3)cc2)CC1

nearest known ligand 0.36

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
SPHK1 Q9NYA1 13/20 0.36
RARB P10826 2/20 0.34
RARA P10276 1/20 0.34
RARG P13631 1/20 0.34
SPHK2 Q9NRA0 7/20 0.33
S1PR1 P21453 1/20 0.33
GAA P10253 1/20 0.31
MAPT P10636 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7911103 0.95 MAPT (0.33) SPHK1GAAMAPT
SCHEMBL8834634 0.94 MAPT (0.35) SPHK1RARBRARARARGGAA
SCHEMBL8833883 0.94 SPHK1 (0.40) SPHK1RARBRARARARGSPHK2
SCHEMBL8834409 0.93 ESR2 (0.33) GAAMAPT
SCHEMBL8833853 0.92 RARB (0.37) RARBRARARARGS1PR1
SCHEMBL8834512 0.90 GAA (0.31) GAAMAPT
SCHEMBL8834513 0.90 GAA (0.31) GAAMAPT
SCHEMBL8834055 0.89 RARB (0.35) RARBRARARARGS1PR1
SCHEMBL7914144 0.89 CYP2C9 (0.39) S1PR1MAPT
SCHEMBL7917430 0.88 MAPT (0.33) SPHK1S1PR1GAAMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0640578-B1 Novel liquid crystalline compound having a 1,1,2,3,3,3,-hexafluoropropyl group and liquid crystal composition CHISSO CORP (JP) 1997-11-05 EP disclosed
EP-0640578-A1 Novel liquid crystalline compound having a 1,1,2,3,3,3,-hexafluoropropyl group and liquid crystal composition Chisso Corporation (JP) 1995-03-01 EP disclosed