Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 5/20 | 1.00 |
| ▸ | EGFR | P00533 | 5/20 | 0.68 |
| ▸ | SRC | P12931 | 4/20 | 0.68 |
| ▸ | PRKD3 | O94806 | 3/20 | 0.68 |
| ▸ | PRKCG | P05129 | 3/20 | 0.68 |
| ▸ | PRKCB | P05771 | 3/20 | 0.68 |
| ▸ | PRKCA | P17252 | 3/20 | 0.68 |
| ▸ | PRKCH | P24723 | 3/20 | 0.68 |
| ▸ | PRKCI | P41743 | 3/20 | 0.68 |
| ▸ | PRKCE | Q02156 | 3/20 | 0.68 |
| ▸ | PRKCQ | Q04759 | 3/20 | 0.68 |
| ▸ | PRKCZ | Q05513 | 3/20 | 0.68 |
| ▸ | PRKCD | Q05655 | 3/20 | 0.68 |
| ▸ | PRKD1 | Q15139 | 3/20 | 0.68 |
| ▸ | ABL1 | P00519 | 1/20 | 0.68 |
| ▸ | ABL2 | P42684 | 1/20 | 0.68 |
| ▸ | MEN1 | O00255 | 2/20 | 0.67 |
| ▸ | MAPT | P10636 | 2/20 | 0.67 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.67 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.67 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8834106 | 0.82 | EGFR (0.71) | BRAFEGFRSRCPRKD3PRKCG | |
| SCHEMBL8834907 | 0.82 | EGFR (0.87) | BRAFEGFRSRCPRKD3PRKCG | |
| SCHEMBL8834327 | 0.81 | EGFR (1.00) | BRAFEGFRSRCPRKD3PRKCG | |
| Daph SCHEMBL11017 | 0.80 | EGFR (1.00) | BRAFEGFRSRCPRKD3PRKCG | |
| SCHEMBL8834950 | 0.80 | EGFR (0.68) | BRAFEGFRSRCPRKD3PRKCG | |
| SCHEMBL8834522 | 0.80 | EGFR (0.68) | BRAFEGFRSRCPRKD3PRKCG | |
| SCHEMBL8834415 | 0.80 | BRAF (0.67) | BRAFEGFRSRCPRKD3PRKCG | |
| SCHEMBL8834607 | 0.80 | BRAF (0.66) | BRAFEGFRSRCPRKD3PRKCG | |
| SCHEMBL8834026 | 0.79 | BRAF (0.72) | BRAFEGFRSRCPRKD3PRKCG | |
| SCHEMBL8835011 | 0.79 | EGFR (0.75) | BRAFEGFRSRCPRKD3PRKCG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5663336-A | IMIDATION OF DIAMINOPHTHALIC ACID TO FORM KINASE INHIBITORS AS ANTITUMOR AGENTS | CIBA-GEIGY CORPORATION (US) | 1997-09-02 | — | — | US | disclosed |
| US-5491144-A | KINASE INHIBITORS, ANTITUMOR AGENTS | CIBA-GEIGY CORPORATION (US) | 1996-02-13 | — | — | US | disclosed |
| EP-0516588-B1 | Substituted diaminophtalimides and analogues | CIBA GEIGY AG (CH) | 1994-07-13 | — | — | EP | disclosed |
| EP-0516588-A1 | Substituted diaminophtalimides and analogues | CIBA-GEIGY AG (CH) | 1992-12-02 | — | — | EP | disclosed |