Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 16/20 | 0.57 |
| ▸ | MAPK11 | Q15759 | 3/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.47 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.44 |
| ▸ | CSNK1A1 | P48729 | 2/20 | 0.42 |
| ▸ | CSNK1D | P48730 | 2/20 | 0.42 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.42 |
| ▸ | GRM5 | P41594 | 1/20 | 0.42 |
| ▸ | SRC | P12931 | 2/20 | 0.41 |
| ▸ | BRAF | P15056 | 2/20 | 0.41 |
| ▸ | KDR | P35968 | 2/20 | 0.41 |
| ▸ | EGFR | P00533 | 1/20 | 0.41 |
| ▸ | RAF1 | P04049 | 1/20 | 0.41 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.41 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.41 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.41 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8835977 | 1.00 | MAPK14 (0.57) | MAPK14MAPK11KCNH2MAPK13CYP2C9 | |
| SCHEMBL20376835 | 0.84 | MAPK14 (0.55) | MAPK14MAPK11KCNH2MAPK13MAPK12 | |
| SCHEMBL8835906 | 0.82 | MAPK14 (0.62) | MAPK14MAPK11MAPK13MAPK12CSNK1A1 | |
| SCHEMBL7499619 | 0.81 | MAPK14 (0.53) | MAPK14MAPK11KCNH2MAPK13CYP2C9 | |
| SCHEMBL25269361 | 0.77 | MAPK14 (0.52) | MAPK14MAPK11KCNH2MAPK13CYP2C9 | |
| SCHEMBL7493509 | 0.76 | MAPK14 (0.45) | MAPK14MAPK11KCNH2MAPK13CYP2C9 | |
| SCHEMBL8836397 | 0.75 | MAPK14 (0.54) | MAPK14MAPK11MAPK13MAPK12CSNK1A1 | |
| SCHEMBL2522580 | 0.74 | MAPK14 (0.62) | MAPK14CSNK1A1CSNK1DCSNK1ESRC | |
| SCHEMBL7488387 | 0.74 | MAPK14 (0.48) | MAPK14MAPK11KCNH2MAPK13CYP2C9 | |
| SCHEMBL7496496 | 0.74 | MAPK14 (0.48) | MAPK14MAPK11KCNH2MAPK13CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5624931-A | Pyrazole derivatives | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1997-04-29 | — | — | US | disclosed |
| US-5478827-A | Inhibits Interleukin-1 and tumor necrosis factor production | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1995-12-26 | — | — | US | disclosed |
| US-5356897-A | Inhibit the production of Interleukin-1 and tumor necrosis factor; administering for treatment of chronic inflammatory diseases, autoimmune diseases and sepsis-induced organ injury | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1994-10-18 | — | — | US | disclosed |
| EP-0531901-A2 | Condensed pyrazole derivatives with interleukin-1 and tumour necrosis factor inhibitory activity | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1993-03-17 | — | — | EP | disclosed |