Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE | P12821 | 2/20 | 0.48 |
| ▸ | F2 | P00734 | 1/20 | 0.46 |
| ▸ | F10 | P00742 | 1/20 | 0.46 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.46 |
| ▸ | BTK | Q06187 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8837660 | 1.00 | ACE (0.48) | ACEF2F10PRSS1BTK | |
| SCHEMBL8837664 | 1.00 | ACE (0.48) | ACEF2F10PRSS1BTK | |
| SCHEMBL7910653 | 0.86 | GAA (0.43) | ACEF2F10PRSS1BTK | |
| SCHEMBL7910651 | 0.86 | GAA (0.43) | ACEF2F10PRSS1BTK | |
| SCHEMBL7339777 | 0.84 | F2 (0.43) | F2F10PRSS1BTKKMT2A | |
| SCHEMBL7339770 | 0.84 | F2 (0.43) | F2F10PRSS1BTKKMT2A | |
| SCHEMBL7339763 | 0.84 | F2 (0.43) | ACEF2F10PRSS1BTK | |
| SCHEMBL7347648 | 0.83 | F2 (0.42) | ACEF2F10PRSS1BTK | |
| SCHEMBL7350194 | 0.82 | F2 (0.42) | F2F10PRSS1BTKKMT2A | |
| SCHEMBL7350200 | 0.82 | F2 (0.42) | F2F10PRSS1BTKKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5654294-A | CARDIOVASCULAR DISORDERS | BRISTOL-MYERS SQUIBB (US) | 1997-08-05 | — | — | US | disclosed |
| US-5646276-A | ANGIOTENSIN CONVERTING ENZYME AND NEUTRAL ENDOPEPTIDASE INHIBITORS; CARDIOVASCULAR DISORDERS | BRISTOL-MYERS SQUIBB CO. (US) | 1997-07-08 | — | — | US | disclosed |
| US-5552397-A | HYPOTENSIVE AGENTS | E. R. SQUIBB & SONS, INC. (US) | 1996-09-03 | — | — | US | disclosed |