SCHEMBL8840271

SCHEMBL8840271

O=C(NC(=O)c1c(F)cccc1F)Nc1cc(Cl)c(F)c(Cl)c1

nearest known ligand 0.69

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 3/20 0.69
KMT2A Q03164 3/20 0.69
MAPT P10636 3/20 0.49
USP2 O75604 1/20 0.49
ALOX15 P16050 1/20 0.49
TLR7 Q9NYK1 1/20 0.49
NPC1 O15118 2/20 0.47
RAB9A P51151 2/20 0.47
PKM P14618 1/20 0.47
ATM Q13315 1/20 0.47
PPIA P62937 2/20 0.46
JAK2 O60674 2/20 0.46
JAK1 P23458 2/20 0.46
TYK2 P29597 2/20 0.46
POLB P06746 1/20 0.45
GAA P10253 3/20 0.45
SLC2A1 P11166 1/20 0.44
HTT P42858 1/20 0.44
NOD2 Q9HC29 1/20 0.44
KDM4E B2RXH2 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8840363 0.94 MEN1 (0.62) MEN1KMT2AMAPTTLR7NPC1
SCHEMBL8840302 0.91 MEN1 (0.65) MEN1KMT2AMAPTUSP2ALOX15
SCHEMBL8660069 0.90 MEN1 (0.60) MEN1KMT2AMAPTUSP2ALOX15
SCHEMBL8840274 0.90 MEN1 (0.60) MEN1KMT2AMAPTUSP2ALOX15
SCHEMBL8840240 0.90 MEN1 (0.56) MEN1KMT2AMAPTTLR7NPC1
SCHEMBL8840257 0.89 MEN1 (0.59) MEN1KMT2AMAPTUSP2ALOX15
SCHEMBL7609081 0.87 SLC2A1 (0.61) MEN1KMT2AMAPTUSP2ALOX15
SCHEMBL30499688 0.87 SLC2A1 (0.61) MEN1KMT2AMAPTUSP2ALOX15
SCHEMBL15335264 0.87 MEN1 (0.59) MEN1KMT2AMAPTUSP2ALOX15
SCHEMBL8840288 0.86 MEN1 (0.59) MEN1KMT2AMAPTTLR7NPC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5607977-A PESTICIDES SHELL AGRAR GMBH & CO. KG (DE) 1997-03-04 US disclosed