SCHEMBL8840323

SCHEMBL8840323

CC1CCC(=O)N1CC#CCN1CCC1

nearest known ligand 0.94

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
CHRM2 P08172 11/20 0.94
CHRM4 P08173 11/20 0.94
CHRM5 P08912 11/20 0.94
CHRM1 P11229 11/20 0.94
CHRM3 P20309 11/20 0.94
CYP1A2 P05177 1/20 0.46
CYP2D6 P10635 1/20 0.46
CYP2C9 P11712 1/20 0.46
CYP2C19 P33261 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11728856 0.97 CHRM2 (1.00) CHRM2CHRM4CHRM5CHRM1CHRM3
SCHEMBL9031196 0.80 CHRM2 (0.67) CHRM2CHRM4CHRM5CHRM1CHRM3
SCHEMBL9024455 0.80 CHRM2 (0.67) CHRM2CHRM4CHRM5CHRM1CHRM3
SCHEMBL9029692 0.75 CHRM2 (0.78) CHRM2CHRM4CHRM5CHRM1CHRM3
SCHEMBL9827225 0.75 CHRM2 (0.64) CHRM2CHRM4CHRM5CHRM1CHRM3
SCHEMBL3924220 0.74 CHRM2 (0.58) CHRM2CHRM4CHRM5CHRM1CHRM3
SCHEMBL11731840 0.74 CHRM2 (0.58) CHRM2CHRM4CHRM5CHRM1CHRM3
SCHEMBL8840326 0.74 CHRM2 (0.58) CHRM2CHRM4CHRM5CHRM1CHRM3
SCHEMBL10562439 0.73 CHRM2 (0.61) CHRM2CHRM4CHRM5CHRM1CHRM3
SCHEMBL10561681 0.73 CHRM2 (0.60) CHRM2CHRM4CHRM5CHRM1CHRM3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-1994023719-A1 OPHTHALMIC USE OF MUSCARINIC AGONISTS HAVING INCREASED DURATION OF ACTIVITY ALLERGAN, INC. (US) 1994-10-27 WO claimed
EP-3377106-B1 MODULATION OF CILIOGENESIS ACADEMISCH ZIEKENHUIS LEIDEN A/U LEIDEN UNIV MEDICAL CENTER (NL) 2023-05-24 EP disclosed
CN-115227822-A Regulating cilia production 莱顿大学医学中心附属莱顿教学医院 2022-10-25 CN disclosed
US-20220133766-A1 MODULATION OF CILIOGENESIS ACADEMISCH ZIEKENHUIS LEIDEN A/U LEIDEN UNIV MEDICAL CENTER (NL) 2022-05-05 US disclosed
US-5677327-A MEASURING THE AGONIST ACTIVITY OF THE COMPOUND AT M3 AND M5 MUSCARINIC RECEPTORS AND DETERMINING FROM SAID ACTIVITY THAT THE COMPOUND WHICH HAS ATLEAST TWICE THE AGONIST ACTIVITY AT M5 RECEPTOR AS COMPARED TO M3 RECEPTOR IS SUITABLE AGONIST ALLERGAN (US) 1997-10-14 US disclosed
US-5521210-A Ophthalmic use of muscarinic agonists having increased duration of activity ALLERGAN, INC. (US) 1996-05-28 US disclosed
WO-1994023719-A1 OPHTHALMIC USE OF MUSCARINIC AGONISTS HAVING INCREASED DURATION OF ACTIVITY ALLERGAN, INC. (US) 1994-10-27 WO disclosed