Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRSS1 | P07477 | 7/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | PLAU | P00749 | 5/20 | 0.43 |
| ▸ | F2 | P00734 | 2/20 | 0.43 |
| ▸ | PLG | P00747 | 2/20 | 0.43 |
| ▸ | PLAT | P00750 | 2/20 | 0.43 |
| ▸ | KLK1 | P06870 | 1/20 | 0.43 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.42 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.42 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.42 |
| ▸ | CDK9 | P50750 | 1/20 | 0.42 |
| ▸ | F10 | P00742 | 1/20 | 0.41 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP2E1 | P05181 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29524321 | 1.00 | PRSS1 (0.48) | PRSS1MEN1MAPTKMT2ASMN1; SMN2 | |
| SCHEMBL548424 | 0.81 | MAPT (0.39) | MEN1MAPTKMT2ASMN1; SMN2NPC1 | |
| SCHEMBL549293 | 0.78 | MAP4K4 (0.59) | MEN1MAPTKMT2ASMN1; SMN2NPC1 | |
| SCHEMBL30450715 | 0.78 | NPC1 (0.60) | MEN1MAPTKMT2ASMN1; SMN2NPC1 | |
| SCHEMBL29014990 | 0.78 | NPC1 (0.60) | MEN1MAPTKMT2ASMN1; SMN2NPC1 | |
| SCHEMBL1798065 | 0.77 | NQO2 (0.46) | PRSS1NPC1PRSS2PRSS3 | |
| SCHEMBL8842460 | 0.77 | MEN1 (0.50) | MEN1MAPTKMT2ASMN1; SMN2NPC1 | |
| Hydrochloric Acid SCHEMBL8842387 | 0.77 | MAP4K4 (0.58) | PRSS1MEN1MAPTKMT2ASMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL1796099 | 0.76 | NQO2 (0.45) | PRSS1NPC1PLAU | |
| SCHEMBL395340 | 0.75 | PRSS1 (0.55) | PRSS1PRSS2PRSS3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5686456-A | DIARYLPYRIMIDINES | THE UNIVERSITY OF NORTH CAROLINA (US) | 1997-11-11 | — | — | US | disclosed |
| US-5622955-A | ADMINISTERING 2,4-BIS-/4-GUANYLPHENYL/-PYRIMIDINE OR DERIVATIVES | THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) | 1997-04-22 | — | — | US | disclosed |
| US-5606058-A | HAVING REDUCED SIDE EFFECTS | THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) | 1997-02-25 | — | — | US | disclosed |
| US-5521189-A | PYRIMIDINE COMPOUNDS AS ANTIPROTOZOA AGENTS | THE UNIVERSITY OF NC AT CH (US) | 1996-05-28 | — | — | US | disclosed |