Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNA5 | P22460 | 16/20 | 0.82 |
| ▸ | KCNH2 | Q12809 | 8/20 | 0.66 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.41 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.41 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.40 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.40 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.40 |
| ▸ | PDE4A | P27815 | 1/20 | 0.39 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.39 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.39 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2063693 | 1.00 | KCNA5 (0.82) | KCNA5KCNH2CYP11B1CYP11B2KEAP1 | |
| SCHEMBL884608 | 0.91 | KCNA5 (1.00) | KCNA5KCNH2CYP11B1CYP11B2KEAP1 | |
| SCHEMBL884655 | 0.88 | KCNA5 (0.70) | KCNA5KCNH2PTGS2 | |
| SCHEMBL2063340 | 0.86 | KCNA5 (0.67) | KCNA5KCNH2PTGS2 | |
| SCHEMBL2062831 | 0.81 | KCNA5 (0.61) | KCNA5KCNH2PTGS2 | |
| SCHEMBL885066 | 0.80 | KCNA5 (0.85) | KCNA5KCNH2CYP11B1CYP11B2KEAP1 | |
| SCHEMBL884739 | 0.80 | KCNA5 (0.78) | KCNA5KCNH2 | |
| SCHEMBL884504 | 0.78 | KCNA5 (0.76) | KCNA5KCNH2CYP11B1CYP11B2KEAP1 | |
| SCHEMBL884970 | 0.78 | KCNA5 (0.75) | KCNA5KCNH2 | |
| SCHEMBL884480 | 0.76 | KCNA5 (0.71) | KCNA5KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1940406-A2 | POTASSIUM CHANNEL INHIBITORS | Merck and Co., Inc. (US) | 2008-07-09 | — | — | EP | claimed |
| WO-2007050348-A2 | POTASSIUM CHANNEL INHIBITORS | MERCK & CO., INC. (US) | 2007-05-03 | — | — | WO | claimed |