SCHEMBL8845705

SCHEMBL8845705

Nc1nc(=O)n(COCCO)cc1I

nearest known ligand 0.44

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
PNP P00491 8/20 0.44
USP2 O75604 1/20 0.44
TSHR P16473 1/20 0.44
EDNRA P25101 1/20 0.44
HTR2A P28223 1/20 0.44
RECQL P46063 1/20 0.44
BLM P54132 1/20 0.44
HBB P68871 1/20 0.44
HSD17B10 Q99714 1/20 0.44
UPP1 Q16831 1/20 0.36
HPRT1 P00492 3/20 0.33
ADORA2A P29274 1/20 0.32
ADORA1 P30542 1/20 0.32
HTT P42858 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17880889 0.81 PNP (0.43) PNPUSP2TSHREDNRAHTR2A
SCHEMBL8845431 0.76 PNP (0.39) PNPUSP2TSHREDNRAHTR2A
SCHEMBL8845687 0.73 FGFR1 (0.47) PNPUSP2TSHREDNRAHTR2A
Phosphoric Acid SCHEMBL9369722 0.72 PNP (0.37) PNPUSP2TSHREDNRAHTR2A
SCHEMBL1834796 0.71 UPP1 (0.57) PNPUSP2TSHREDNRAHTR2A
SCHEMBL8441851 0.70 DYRK3 (0.54) PNPUSP2TSHREDNRAHTR2A
SCHEMBL12870924 0.69 KMT2A (0.37)
SCHEMBL18890917 0.68 PNP (0.41) PNPUSP2TSHREDNRAHTR2A
SCHEMBL24114956 0.68 PNP (0.41) PNPUSP2TSHREDNRAHTR2A
SCHEMBL14612879 0.68 EP300 (0.40) PNPUSP2TSHREDNRAHTR2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2403863-B1 NUCLEIC ACID CHEMICAL MODIFICATIONS ALNYLAM PHARMACEUTICALS INC (US) 2013-08-28 EP disclosed
US-5625081-A XANTHENE DYE DERIVATIVES E. I. DU PONT DE NEMOURS AND COMPANY (US) 1997-04-29 US disclosed
US-5608063-A Method, system and reagents for DNA sequencing E. I. DU PONT DE NEMOURS AND COMPANY (US) 1997-03-04 US disclosed
US-5558991-A DNA sequencing method using acyclonucleoside triphosphates E. I. DU PONT DE NEMOURS AND COMPANY (US) 1996-09-24 US disclosed
EP-0252683-B1 Process and reagents for DNA sequence analysis DU PONT (US) 1995-01-18 EP disclosed
EP-0251786-B1 Alkynylamino-nucleotides DU PONT (US) 1994-11-30 EP disclosed
US-5332666-A Reporter-labeled chain terminator reacted with DNA nucleotides E. I. DU PONT DE NEMOURS AND COMPANY (US) 1994-07-26 US disclosed
US-5306618-A Using xanthene dye reporter labeled DNA fragments E. I. DU PONT DE NEMOURS AND COMPANY (US) 1994-04-26 US disclosed
US-5242796-A Fluorescent xanthene dye E. I. DU PONT DE NEMOURS AND COMPANY (US) 1993-09-07 US disclosed
US-5151507-A Alkynylamino-nucleotides E. I. DU PONT DE NEMOURS AND COMPANY (US) 1992-09-29 US disclosed
US-5047519-A Alkynylamino-nucleotides E. I. DU PONT DE NEMOURS AND COMPANY (US) 1991-09-10 US disclosed
EP-0252683-A2 Process and reagents for DNA sequence analysis E.I. DU PONT DE NEMOURS AND COMPANY (US) 1988-01-13 EP disclosed
EP-0251786-A2 Alkynylamino-nucleotides E.I. DU PONT DE NEMOURS AND COMPANY (US) 1988-01-07 EP disclosed