Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNA5 | P22460 | 14/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 5/20 | 0.44 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.38 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | GFER | P55789 | 1/20 | 0.36 |
| ▸ | CFTR | P13569 | 1/20 | 0.33 |
| ▸ | GOPC | Q9HD26 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL886468 | 0.91 | KCNA5 (0.39) | KCNA5KCNH2SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL884227 | 0.81 | KCNA5 (0.47) | KCNA5KCNH2ALDH1A1 | |
| SCHEMBL884568 | 0.80 | KCNA5 (0.45) | KCNA5KCNH2ALDH1A1MAPTKDM4E | |
| SCHEMBL885030 | 0.80 | KCNA5 (0.45) | KCNA5KCNH2SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL2062758 | 0.79 | KCNA5 (0.45) | KCNA5KCNH2SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL2063380 | 0.79 | KCNA5 (0.44) | KCNA5KCNH2SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL1367898 | 0.79 | KDM4E (0.32) | KCNA5ALDH1A1MAPTKDM4EGFER | |
| SCHEMBL885762 | 0.78 | KCNA5 (0.43) | KCNA5KCNH2 | |
| SCHEMBL2063804 | 0.78 | KCNA5 (0.47) | KCNA5KCNH2SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL884252 | 0.76 | KCNA5 (0.48) | KCNA5KCNH2SLC6A2SLC6A4SLC6A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1940406-A2 | POTASSIUM CHANNEL INHIBITORS | Merck and Co., Inc. (US) | 2008-07-09 | — | — | EP | claimed |
| WO-2007050348-A2 | POTASSIUM CHANNEL INHIBITORS | MERCK & CO., INC. (US) | 2007-05-03 | — | — | WO | claimed |