Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Propylene Glycol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | NR2E1 | Q9Y466 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 3/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.35 |
| ▸ | CA1 | P00915 | 1/20 | 0.35 |
| ▸ | CA2 | P00918 | 1/20 | 0.35 |
| ▸ | CA4 | P22748 | 1/20 | 0.35 |
| ▸ | CA7 | P43166 | 1/20 | 0.35 |
| ▸ | CA9 | Q16790 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 2/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Propylene Glycol SCHEMBL8505000 | 0.95 | TDP1 (0.50) | TDP1USP2SMN1; SMN2NR2E1LMNA | |
| SCHEMBL5027030 | 0.91 | — | — | |
| SCHEMBL764019 | 0.91 | — | — | |
| SCHEMBL1487123 | 0.91 | — | — | |
| Isopropyl Alcohol SCHEMBL8330958 | 0.88 | SMN1; SMN2 (0.41) | TDP1USP2SMN1; SMN2NR2E1LMNA | |
| Ether SCHEMBL7734870 | 0.84 | USP2 (0.42) | TDP1USP2SMN1; SMN2NR2E1LMNA | |
| SCHEMBL1838995 | 0.84 | USP2 (0.45) | TDP1USP2SMN1; SMN2NR2E1LMNA | |
| Propylene Glycol SCHEMBL8927832 | 0.80 | TDP1 (0.56) | TDP1SMN1; SMN2NR2E1LMNAMEN1 | |
| Glycerin SCHEMBL8592118 | 0.77 | TDP1 (0.67) | TDP1USP2LMNACYP1A2KDM4E | |
| SCHEMBL1838790 | 0.77 | SMN1; SMN2 (0.47) | TDP1SMN1; SMN2NR2E1LMNAMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0783245-A1 | DISINFECTANT COMPOSITIONS | UNILEVER N.V. (NL) | 1997-07-16 | — | — | EP | disclosed |
| WO-1996009761-A1 | DISINFECTANT COMPOSITIONS | UNILEVER N.V. (NL) | 1996-04-04 | — | — | WO | disclosed |