Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNA5 | P22460 | 17/20 | 0.74 |
| ▸ | KCNH2 | Q12809 | 7/20 | 0.68 |
| ▸ | KCNN4 | O15554 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | CFTR | P13569 | 1/20 | 0.46 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.46 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.46 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.46 |
| ▸ | GOPC | Q9HD26 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL885826 | 0.94 | KCNA5 (0.74) | KCNA5KCNH2KCNN4TSHRMAPK1 | |
| SCHEMBL885170 | 0.93 | KCNA5 (0.68) | KCNA5KCNH2KCNN4TSHRMAPK1 | |
| SCHEMBL884939 | 0.89 | KCNA5 (0.64) | KCNA5KCNH2 | |
| SCHEMBL884508 | 0.89 | KCNA5 (0.64) | KCNA5KCNH2SMN1; SMN2 | |
| SCHEMBL884536 | 0.89 | KCNA5 (0.75) | KCNA5KCNH2 | |
| SCHEMBL885216 | 0.85 | KCNA5 (0.74) | KCNA5KCNH2 | |
| SCHEMBL884613 | 0.85 | KCNA5 (0.63) | KCNA5KCNH2 | |
| SCHEMBL885138 | 0.85 | KCNA5 (1.00) | KCNA5KCNH2KCNN4 | |
| SCHEMBL885908 | 0.85 | KCNA5 (0.60) | KCNA5KCNH2 | |
| SCHEMBL884767 | 0.85 | KCNA5 (0.77) | KCNA5KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1940406-A2 | POTASSIUM CHANNEL INHIBITORS | Merck and Co., Inc. (US) | 2008-07-09 | — | — | EP | claimed |
| WO-2007050348-A2 | POTASSIUM CHANNEL INHIBITORS | MERCK & CO., INC. (US) | 2007-05-03 | — | — | WO | claimed |