Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 | P08172 | 7/20 | 0.65 |
| ▸ | CHRM4 | P08173 | 7/20 | 0.65 |
| ▸ | CHRM5 | P08912 | 7/20 | 0.65 |
| ▸ | CHRM1 | P11229 | 7/20 | 0.65 |
| ▸ | CHRM3 | P20309 | 7/20 | 0.65 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8847729 | 1.00 | CHRM2 (0.65) | CHRM2CHRM4CHRM5CHRM1CHRM3 | |
| SCHEMBL10395595 | 0.89 | CHRM2 (0.63) | CHRM2CHRM4CHRM5CHRM1CHRM3 | |
| Hydrochloric Acid SCHEMBL9192585 | 0.88 | CHRM2 (0.61) | CHRM2CHRM4CHRM5CHRM1CHRM3 | |
| SCHEMBL9728616 | 0.86 | CHRM2 (0.62) | CHRM2CHRM4CHRM5CHRM1CHRM3 | |
| SCHEMBL10395608 | 0.82 | CHRM2 (0.58) | CHRM2CHRM4CHRM5CHRM1CHRM3 | |
| SCHEMBL10395609 | 0.82 | CHRM2 (0.58) | CHRM2CHRM4CHRM5CHRM1CHRM3 | |
| SCHEMBL10396161 | 0.81 | CHRM2 (0.57) | CHRM2CHRM4CHRM5CHRM1CHRM3 | |
| SCHEMBL10396162 | 0.81 | CHRM2 (0.57) | CHRM2CHRM4CHRM5CHRM1CHRM3 | |
| SCHEMBL8848052 | 0.76 | CHRM2 (0.51) | CHRM2CHRM4CHRM5CHRM1CHRM3 | |
| SCHEMBL9193255 | 0.76 | CHRM2 (0.66) | CHRM2CHRM4CHRM5CHRM1CHRM3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5637731-A | CHOLINERGIC AGENTS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1997-06-10 | — | — | US | disclosed |
| US-5550257-A | TREATING CENTRAL CHOLINERGIC DYSFUNCTION | AMERICAN CYANAMID COMPANY (US) | 1996-08-27 | — | — | US | disclosed |
| US-5451685-A | MANUFACTURING PHARMACEUTICALS | AMERICAN CYANAMID COMPANY (US) | 1995-09-19 | — | — | US | disclosed |
| US-5356885-A | Cholinergic agents; administering for treatment of diseases of the central nervous system | AMERICAN CYANAMID COMPANY (US) | 1994-10-18 | — | — | US | disclosed |
| EP-0510333-A1 | Substituted oxotremorine derivatives | AMERICAN CYANAMID COMPANY (US) | 1992-10-28 | — | — | EP | disclosed |