Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 1/20 | 0.31 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.30 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8847605 | 0.94 | — | — | |
| SCHEMBL8848122 | 0.85 | — | — | |
| SCHEMBL7546081 | 0.80 | MEN1 (0.33) | KCNH2 | |
| SCHEMBL8847833 | 0.78 | — | — | |
| SCHEMBL8847738 | 0.78 | — | — | |
| SCHEMBL8848457 | 0.72 | — | — | |
| SCHEMBL4723833 | 0.65 | TLR8 (0.38) | TLR8TLR7 | |
| SCHEMBL13361150 | 0.64 | KCNH2 (0.38) | KCNH2TLR7 | |
| SCHEMBL8848094 | 0.64 | — | — | |
| SCHEMBL30889344 | 0.63 | TSHR (0.40) | KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5614519-A | (1-(2,3 or 4-N-morpholinoalkyl)-imidazol-4-yl)-benizimidazol-1-yl-methyl]-biphenyls useful as angiotensin-II antagonists | KARL THOMAE GMBH (DE) | 1997-03-25 | — | — | US | disclosed |
| US-5602127-A | ADMINISTERING TO TREAT HYPERTENSION | KARL THOMAE GMBH (DE) | 1997-02-11 | — | — | US | disclosed |
| US-5594003-A | HYPOTENSIVE AGENTS | DR. KARL THOMAE GMBH (DE) | 1997-01-14 | — | — | US | disclosed |
| US-5591762-A | HYPOTENSIVE AGENTS | DR. KARL THOMAE GMBH (DE) | 1997-01-07 | — | — | US | disclosed |
| EP-0566020-A1 | Benzimidazoles, pharmaceutical compositions thereof and processes for their preparation | Dr. Karl Thomae GmbH (DE) | 1993-10-20 | — | — | EP | disclosed |