Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Methacrylic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | TSHR | P16473 | 3/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | THRB | P10828 | 2/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Methacrylic Acid SCHEMBL8850627 | 1.00 | MEN1 (0.41) | MEN1KMT2ATSHRTDP1MAPK1 | |
| Di(Hydroxyethyl)Ether SCHEMBL11030060 | 0.98 | TSHR (0.39) | MEN1KMT2ATSHRTDP1MAPK1 | |
| Triethylene Glycol SCHEMBL11039920 | 0.91 | TSHR (0.33) | MEN1KMT2ATSHRTDP1MAPK1 | |
| Methacrylic Acid SCHEMBL27839345 | 0.89 | HSD17B10 (0.42) | MEN1KMT2ATSHRTDP1MAPK1 | |
| Methacrylic Acid SCHEMBL10893406 | 0.89 | HSD17B10 (0.42) | MEN1KMT2ATSHRTDP1MAPK1 | |
| Methacrylic Acid SCHEMBL9719219 | 0.89 | HSD17B10 (0.42) | MEN1KMT2ATSHRTDP1MAPK1 | |
| Tetraethylene Glycol SCHEMBL33688 | 0.88 | MEN1 (0.52) | MEN1KMT2ATSHRTDP1MAPK1 | |
| Tetraethylene Glycol SCHEMBL9314003 | 0.88 | MEN1 (0.52) | MEN1KMT2ATSHRTDP1MAPK1 | |
| Methacrylic Acid SCHEMBL10529387 | 0.88 | MEN1 (0.52) | MEN1KMT2ATSHRTDP1MAPK1 | |
| Methacrylic Acid SCHEMBL9485971 | 0.88 | MEN1 (0.52) | MEN1KMT2ATSHRTDP1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0661307-B1 | Transparent resin and plastic lens | HITACHI CHEMICAL CO LTD (JP) | 1997-10-15 | — | — | EP | disclosed |
| US-5663264-A | OF A COPOLYMER CONTAINING AN ALKYLENE OXIDE MONOMER, A POLYFUNCTIONAL (METH)ACRYLATE MONOMER AND A VINYL MONOMER | HITACHI CHEMICAL COMPANY, LTD. (JP) | 1997-09-02 | — | — | US | disclosed |
| US-5583191-A | FORMED OF TRANSPARENT RESIN OBTAINED BY POLYMERIZING MONOMER HAVING ALKYLENE OXIDE GROUP, POLYFUNCTIONAL (METH)ACRYLATE HAVING DIVALENT BRANCED HYDROCARBON GROUP, OPTIONAL ADDITIONAL VINYL MONOMER; HEAT RESISTANCE | HITACHI CHEMICAL COMPANY, LTD. (JP) | 1996-12-10 | — | — | US | disclosed |
| EP-0661307-A2 | Transparent resin and plastic lens | HITACHI CHEMICAL CO., LTD. (JP) | 1995-07-05 | — | — | EP | disclosed |