Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNA5 | P22460 | 18/20 | 0.78 |
| ▸ | KCNH2 | Q12809 | 9/20 | 0.75 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2063707 | 0.88 | KCNA5 (1.00) | KCNA5KCNH2TSHRMAPK1SMN1; SMN2 | |
| SCHEMBL2062779 | 0.86 | KCNA5 (1.00) | KCNA5KCNH2TSHRMAPK1 | |
| SCHEMBL885074 | 0.85 | KCNA5 (0.81) | KCNA5KCNH2SMN1; SMN2 | |
| SCHEMBL884739 | 0.84 | KCNA5 (0.78) | KCNA5KCNH2 | |
| SCHEMBL884802 | 0.82 | KCNA5 (0.69) | KCNA5KCNH2 | |
| SCHEMBL884970 | 0.82 | KCNA5 (0.75) | KCNA5KCNH2 | |
| SCHEMBL2063325 | 0.81 | KCNA5 (1.00) | KCNA5KCNH2TSHRMAPK1SMN1; SMN2 | |
| SCHEMBL2063340 | 0.80 | KCNA5 (0.67) | KCNA5KCNH2 | |
| SCHEMBL884349 | 0.80 | KCNA5 (0.74) | KCNA5KCNH2TSHRMAPK1SMN1; SMN2 | |
| SCHEMBL884608 | 0.79 | KCNA5 (1.00) | KCNA5KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090233897-A1 | Potassium Channel Inhibitors | MERCK SHARP & DOHME CORP. | 2009-09-17 | — | — | US | claimed |
| EP-1940406-A2 | POTASSIUM CHANNEL INHIBITORS | Merck and Co., Inc. (US) | 2008-07-09 | — | — | EP | claimed |
| WO-2007050348-A2 | POTASSIUM CHANNEL INHIBITORS | MERCK & CO., INC. (US) | 2007-05-03 | — | — | WO | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090233897-A1 | Potassium Channel Inhibitors | KCNJ2, KCNQ2, KCNH2 | KCNA5 11/4885KCNH2 3/4885TSHR 2897/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.