Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4D | Q08499 | 19/20 | 0.64 |
| ▸ | PDE4A | P27815 | 1/20 | 0.45 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.45 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL885140 | 0.90 | PDE4D (0.79) | PDE4DPDE4APDE4BPDE4C | |
| SCHEMBL1434046 | 0.81 | PDE4D (0.61) | PDE4DPDE4APDE4BPDE4C | |
| SCHEMBL885390 | 0.80 | PDE4D (0.77) | PDE4DPDE4APDE4BPDE4C | |
| SCHEMBL885141 | 0.79 | PDE4D (0.56) | PDE4DPDE4APDE4BPDE4C | |
| SCHEMBL885208 | 0.79 | PDE4D (0.87) | PDE4DPDE4APDE4BPDE4C | |
| SCHEMBL1434241 | 0.78 | PDE4D (0.85) | PDE4DPDE4APDE4BPDE4C | |
| SCHEMBL884918 | 0.78 | PDE4D (0.85) | PDE4DPDE4APDE4BPDE4C | |
| SCHEMBL1434339 | 0.78 | PDE4D (0.85) | PDE4DPDE4APDE4BPDE4C | |
| SCHEMBL1434650 | 0.77 | PDE4D (0.85) | PDE4DPDE4APDE4BPDE4C | |
| SCHEMBL1434313 | 0.77 | PDE4D (1.00) | PDE4DPDE4APDE4BPDE4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2125736-A1 | SUBSTITUTED ACETOPHENONES USEFUL AS PDE4 INHIBITORS | Leo Pharma A/S (DK) | 2009-12-02 | — | — | EP | claimed |
| WO-2008077404-A1 | SUBSTITUTED ACETOPHENONES USEFUL AS PDE4 INHIBITORS | LEO PHARMA A/S (DK) | 2008-07-03 | — | — | WO | claimed |
| EP-2125736-A1 | SUBSTITUTED ACETOPHENONES USEFUL AS PDE4 INHIBITORS | Leo Pharma A/S (DK) | 2009-12-02 | — | — | EP | disclosed |
| WO-2008077404-A1 | SUBSTITUTED ACETOPHENONES USEFUL AS PDE4 INHIBITORS | LEO PHARMA A/S (DK) | 2008-07-03 | — | — | WO | disclosed |