Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | GLA | P06280 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | ADK | P55263 | 1/20 | 0.40 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.39 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.38 |
| ▸ | PDE4A | P27815 | 1/20 | 0.38 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.38 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.38 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.38 |
| ▸ | KHK | P50053 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | NAPEPLD | Q6IQ20 | 1/20 | 0.38 |
| ▸ | STK4 | Q13043 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Oxalic Acid SCHEMBL9232767 | 0.96 | TSHR (0.40) | TSHRPOLBALDH1A1NPSR1KDM4E | |
| SCHEMBL8851415 | 0.91 | TSHR (0.43) | TSHRPOLBALDH1A1NPSR1KDM4E | |
| SCHEMBL9231518 | 0.89 | TSHR (0.47) | TSHRPOLBALDH1A1NPSR1KDM4E | |
| SCHEMBL8851394 | 0.89 | POLB (0.44) | TSHRPOLBALDH1A1NPSR1KDM4E | |
| SCHEMBL8851425 | 0.89 | TSHR (0.41) | TSHRPOLBALDH1A1NPSR1KDM4E | |
| SCHEMBL8851055 | 0.89 | HTT (0.42) | TSHRPOLBALDH1A1NPSR1KDM4E | |
| SCHEMBL8851867 | 0.89 | TSHR (0.41) | TSHRPOLBALDH1A1NPSR1KDM4E | |
| SCHEMBL9233803 | 0.88 | POLB (0.43) | TSHRPOLBALDH1A1NPSR1KDM4E | |
| SCHEMBL8851801 | 0.87 | TSHR (0.45) | TSHRPOLBALDH1A1NPSR1KDM4E | |
| SCHEMBL10658223 | 0.87 | KHK (0.44) | TSHRPOLBALDH1A1NPSR1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5618814-A | Trisubstituted pyrimido [5,4-d] pyrimidines for modulating multi-drug resistance and pharmaceutical compositions containing these compounds | DR. KARL THOMAE GMBH (DE) | 1997-04-08 | — | — | US | disclosed |