Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4D | Q08499 | 17/20 | 0.59 |
| ▸ | PDE4A | P27815 | 1/20 | 0.41 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.41 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.41 |
| ▸ | CNR2 | P34972 | 3/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL885141 | 0.90 | PDE4D (0.56) | PDE4DPDE4APDE4BPDE4C | |
| SCHEMBL885083 | 0.87 | PDE4D (0.53) | PDE4DPDE4APDE4BPDE4C | |
| SCHEMBL885362 | 0.83 | PDE4D (0.68) | PDE4DPDE4APDE4BPDE4CCNR2 | |
| SCHEMBL1434241 | 0.82 | PDE4D (0.85) | PDE4DPDE4APDE4BPDE4C | |
| SCHEMBL10194812 | 0.81 | PDE4D (0.66) | PDE4DPDE4APDE4BPDE4C | |
| SCHEMBL1434406 | 0.80 | PDE4D (0.65) | PDE4DPDE4APDE4BPDE4C | |
| SCHEMBL4433401 | 0.79 | PDE4D (0.50) | PDE4DPDE4APDE4BPDE4C | |
| SCHEMBL885272 | 0.78 | PDE4D (0.62) | PDE4DPDE4APDE4BPDE4CCNR2 | |
| SCHEMBL885284 | 0.78 | PDE4D (0.71) | PDE4DPDE4APDE4BPDE4C | |
| SCHEMBL885208 | 0.75 | PDE4D (0.87) | PDE4DPDE4APDE4BPDE4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2125736-A1 | SUBSTITUTED ACETOPHENONES USEFUL AS PDE4 INHIBITORS | Leo Pharma A/S (DK) | 2009-12-02 | — | — | EP | claimed |
| WO-2008077404-A1 | SUBSTITUTED ACETOPHENONES USEFUL AS PDE4 INHIBITORS | LEO PHARMA A/S (DK) | 2008-07-03 | — | — | WO | claimed |
| EP-2125736-A1 | SUBSTITUTED ACETOPHENONES USEFUL AS PDE4 INHIBITORS | Leo Pharma A/S (DK) | 2009-12-02 | — | — | EP | disclosed |
| WO-2008077404-A1 | SUBSTITUTED ACETOPHENONES USEFUL AS PDE4 INHIBITORS | LEO PHARMA A/S (DK) | 2008-07-03 | — | — | WO | disclosed |