Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4D | Q08499 | 15/20 | 0.47 |
| ▸ | PDE4A | P27815 | 2/20 | 0.39 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.39 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.39 |
| ▸ | HTR1A | P08908 | 2/20 | 0.38 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.38 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.38 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.38 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.34 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL885186 | 0.90 | PDE4D (0.56) | PDE4DHTR1AADRA1DADRA1AADRA1B | |
| SCHEMBL885159 | 0.86 | PDE4D (0.53) | PDE4DPDE4APDE4BPDE4CHTR1A | |
| SCHEMBL884882 | 0.84 | PDE4D (0.42) | PDE4DPDE4APDE4BPDE4C | |
| SCHEMBL885108 | 0.83 | PDE4D (0.41) | PDE4DPDE4APDE4BPDE4C | |
| SCHEMBL884956 | 0.83 | PDE4D (0.43) | PDE4DPDE4APDE4BPDE4C | |
| SCHEMBL4432655 | 0.83 | PDE4D (0.51) | PDE4DPDE4APDE4BPDE4CHTR1A | |
| SCHEMBL885345 | 0.82 | PDE4D (0.41) | PDE4DPDE4APDE4BPDE4C | |
| SCHEMBL886775 | 0.82 | PDE4D (0.48) | PDE4DPDE4APDE4BPDE4C | |
| SCHEMBL885385 | 0.82 | PDE4D (0.45) | PDE4DPDE4APDE4BPDE4CHTR1A | |
| SCHEMBL885063 | 0.82 | PDE4D (0.46) | PDE4DHTR1AADRA1DADRA1AADRA1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2125736-A1 | SUBSTITUTED ACETOPHENONES USEFUL AS PDE4 INHIBITORS | Leo Pharma A/S (DK) | 2009-12-02 | — | — | EP | claimed |
| WO-2008077404-A1 | SUBSTITUTED ACETOPHENONES USEFUL AS PDE4 INHIBITORS | LEO PHARMA A/S (DK) | 2008-07-03 | — | — | WO | claimed |
| EP-2125736-A1 | SUBSTITUTED ACETOPHENONES USEFUL AS PDE4 INHIBITORS | Leo Pharma A/S (DK) | 2009-12-02 | — | — | EP | disclosed |
| WO-2008077404-A1 | SUBSTITUTED ACETOPHENONES USEFUL AS PDE4 INHIBITORS | LEO PHARMA A/S (DK) | 2008-07-03 | — | — | WO | disclosed |