Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 1/20 | 0.46 |
| ▸ | IKBKB | O14920 | 8/20 | 0.39 |
| ▸ | CHUK | O15111 | 7/20 | 0.39 |
| ▸ | ALDH2 | P05091 | 4/20 | 0.37 |
| ▸ | CCNC | P24863 | 3/20 | 0.36 |
| ▸ | CDK8 | P49336 | 3/20 | 0.36 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.36 |
| ▸ | AURKA | O14965 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | CASP1 | P29466 | 1/20 | 0.36 |
| ▸ | TTK | P33981 | 1/20 | 0.36 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.36 |
| ▸ | INCENP | Q9NQS7 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28032516 | 0.81 | NOTUM (0.49) | NOTUMIKBKBCHUKALDH2MAP4K4 | |
| SCHEMBL11216346 | 0.79 | AURKA (0.59) | IKBKBCHUKAURKAMAPTTHRB | |
| SCHEMBL10996413 | 0.78 | ERCC1 (0.47) | IKBKBCHUKCCNCCDK8 | |
| SCHEMBL10996103 | 0.78 | IKBKB (0.49) | IKBKBCHUKCCNCCDK8AURKA | |
| SCHEMBL10997791 | 0.78 | TTK (0.45) | NOTUMIKBKBCHUKCCNCCDK8 | |
| SCHEMBL10999074 | 0.77 | PARP1 (0.49) | IKBKBCHUKAURKAMAPTTHRB | |
| SCHEMBL11002057 | 0.77 | AURKB (0.49) | IKBKBCHUKMAP4K4AURKAMAPT | |
| SCHEMBL7291907 | 0.77 | AURKB (0.61) | NOTUMMAP4K4AURKAMAPTTHRB | |
| SCHEMBL8853769 | 0.76 | CCNC (0.64) | IKBKBCHUKCCNCCDK8AURKA | |
| SCHEMBL11000584 | 0.75 | PARP1 (0.49) | MAPTTHRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5698199-A | ORAL ADMINISTRATION OR TOPICAL APPLICATION OF A THISTLE-SERIES OR PEPPER-FAMILY PLANT OR EXTRACT FOR CONTROL, PREVENTION AND IMPROVEMENT OF OBESITY | KAO CORPORATION (JP) | 1997-12-16 | — | — | US | disclosed |