Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4D | Q08499 | 11/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | ERN1 | O75460 | 5/20 | 0.37 |
| ▸ | AR | P10275 | 1/20 | 0.37 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL885299 | 0.90 | PDE4D (0.43) | PDE4DNPC1GAAERN1MDM2 | |
| SCHEMBL4427860 | 0.90 | NPC1 (0.39) | PDE4DNPC1GAAERN1 | |
| SCHEMBL4434300 | 0.88 | PDE4D (0.45) | PDE4D | |
| SCHEMBL4441662 | 0.87 | HSD17B10 (0.37) | PDE4DNPC1GAAERN1 | |
| SCHEMBL4429229 | 0.83 | PDE4D (0.48) | PDE4DNPC1GAAERN1MDM2 | |
| SCHEMBL885256 | 0.83 | PDE4D (0.53) | PDE4D | |
| SCHEMBL885389 | 0.81 | PDE4D (0.51) | PDE4DERN1 | |
| SCHEMBL884956 | 0.80 | PDE4D (0.43) | PDE4D | |
| SCHEMBL4440274 | 0.80 | PDE4D (0.41) | PDE4D | |
| SCHEMBL885352 | 0.80 | PDE4D (0.45) | PDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2125736-A1 | SUBSTITUTED ACETOPHENONES USEFUL AS PDE4 INHIBITORS | Leo Pharma A/S (DK) | 2009-12-02 | — | — | EP | claimed |
| WO-2008077404-A1 | SUBSTITUTED ACETOPHENONES USEFUL AS PDE4 INHIBITORS | LEO PHARMA A/S (DK) | 2008-07-03 | — | — | WO | claimed |
| EP-2125736-A1 | SUBSTITUTED ACETOPHENONES USEFUL AS PDE4 INHIBITORS | Leo Pharma A/S (DK) | 2009-12-02 | — | — | EP | disclosed |
| WO-2008077404-A1 | SUBSTITUTED ACETOPHENONES USEFUL AS PDE4 INHIBITORS | LEO PHARMA A/S (DK) | 2008-07-03 | — | — | WO | disclosed |