Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX1 | P07099 | 1/20 | 0.55 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.50 |
| ▸ | GMNN | O75496 | 1/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | THRB | P10828 | 1/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.50 |
| ▸ | BLM | P54132 | 1/20 | 0.50 |
| ▸ | GPR84 | Q9NQS5 | 10/20 | 0.47 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.47 |
| ▸ | PPARD | Q03181 | 7/20 | 0.45 |
| ▸ | CES2 | O00748 | 1/20 | 0.45 |
| ▸ | LCK | P06239 | 1/20 | 0.45 |
| ▸ | ZDHHC20 | Q5W0Z9 | 1/20 | 0.45 |
| ▸ | ZDHHC2 | Q9UIJ5 | 1/20 | 0.45 |
| ▸ | PPARG | P37231 | 6/20 | 0.43 |
| ▸ | PPARA | Q07869 | 6/20 | 0.43 |
| ▸ | HDAC11 | Q96DB2 | 5/20 | 0.43 |
| ▸ | TSHR | P16473 | 4/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27256564 | 1.00 | EPHX1 (0.55) | EPHX1MAPTHSD17B10GMNNTP53 | |
| SCHEMBL28489308 | 1.00 | EPHX1 (0.55) | EPHX1MAPTHSD17B10GMNNTP53 | |
| SCHEMBL27256562 | 0.98 | EPHX1 (0.52) | EPHX1MAPTHSD17B10GMNNTP53 | |
| Acetic Acid SCHEMBL10544059 | 0.96 | EPHX1 (0.52) | EPHX1MAPTHSD17B10GMNNTP53 | |
| Acetic Acid SCHEMBL11589472 | 0.96 | EPHX1 (0.52) | EPHX1MAPTHSD17B10GMNNTP53 | |
| SCHEMBL5165394 | 0.91 | EPHX1 (0.44) | EPHX1MAPTHSD17B10GMNNTP53 | |
| SCHEMBL2676329 | 0.83 | EPHX1 (0.55) | EPHX1MAPTHSD17B10GMNNTP53 | |
| SCHEMBL1405573 | 0.81 | EPHX1 (0.53) | EPHX1MAPTHSD17B10GMNNTP53 | |
| SCHEMBL11600053 | 0.81 | EPHX1 (0.53) | EPHX1MAPTHSD17B10GMNNTP53 | |
| SCHEMBL624891 | 0.81 | EPHX1 (0.69) | EPHX1MAPTHSD17B10GMNNTP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5656634-A | N-aryl and N-heteroarylamide and urea derivatives as inhibitors of acyl coenzyme A: cholesterol acyl transferase (ACAT) | PFIZER INC. (US) | 1997-08-12 | — | — | US | disclosed |
| EP-0418071-B1 | New N-aryl and N-heteroarylamide and urea derivatives as inhibitors of acyl coenzyme A: cholesterol acyl transferase | PFIZER (US) | 1995-04-26 | — | — | EP | disclosed |
| US-5362878-A | Intermediates for making N-aryl and N-heteroarylamide and urea derivatives as inhibitors of acyl coenzyme A: cholesterol acyl transferase (ACAT) | PFIZER INC. (US) | 1994-11-08 | — | — | US | disclosed |
| EP-0418071-A2 | New N-aryl and N-heteroarylamide and urea derivatives as inhibitors of acyl coenzyme A: cholesterol acyl transferase | PFIZER INC. (US) | 1991-03-20 | — | — | EP | disclosed |