Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HASPIN | Q8TF76 | 9/20 | 0.55 |
| ▸ | GSK3B | P49841 | 2/20 | 0.50 |
| ▸ | DAPK3 | O43293 | 2/20 | 0.48 |
| ▸ | PLK1 | P53350 | 2/20 | 0.48 |
| ▸ | PLK3 | Q9H4B4 | 2/20 | 0.48 |
| ▸ | AURKA | O14965 | 1/20 | 0.48 |
| ▸ | JAK2 | O60674 | 1/20 | 0.48 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.48 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.48 |
| ▸ | CDK1 | P06493 | 1/20 | 0.48 |
| ▸ | PIM1 | P11309 | 1/20 | 0.48 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.48 |
| ▸ | PRKACA | P17612 | 1/20 | 0.48 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.48 |
| ▸ | CDK2 | P24941 | 1/20 | 0.48 |
| ▸ | MARK3 | P27448 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | AKT1 | P31749 | 1/20 | 0.48 |
| ▸ | FLT4 | P35916 | 1/20 | 0.48 |
| ▸ | KDR | P35968 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8856185 | 0.81 | HASPIN (0.36) | HASPINGSK3BDAPK3PLK1PLK3 | |
| SCHEMBL1982292 | 0.80 | TSHR (0.60) | HASPINGSK3BDAPK3PLK1PLK3 | |
| SCHEMBL3609606 | 0.77 | HASPIN (0.56) | HASPINGSK3BDAPK3PLK1PLK3 | |
| SCHEMBL568019 | 0.76 | HASPIN (0.54) | HASPINGSK3BDAPK3PLK1PLK3 | |
| SCHEMBL14423247 | 0.76 | HASPIN (0.54) | HASPINGSK3BDAPK3PLK1PLK3 | |
| SCHEMBL30481290 | 0.76 | HASPIN (0.54) | HASPINGSK3BDAPK3PLK1PLK3 | |
| SCHEMBL2502319 | 0.76 | HASPIN (0.54) | HASPINGSK3BDAPK3PLK1PLK3 | |
| SCHEMBL18935881 | 0.76 | HASPIN (0.54) | HASPINGSK3BDAPK3PLK1PLK3 | |
| SCHEMBL3589139 | 0.76 | HASPIN (0.54) | HASPINGSK3BDAPK3PLK1PLK3 | |
| Bromide SCHEMBL16238937 | 0.75 | HASPIN (0.52) | HASPINGSK3BDAPK3PLK1PLK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5656634-A | N-aryl and N-heteroarylamide and urea derivatives as inhibitors of acyl coenzyme A: cholesterol acyl transferase (ACAT) | PFIZER INC. (US) | 1997-08-12 | — | — | US | disclosed |
| EP-0418071-B1 | New N-aryl and N-heteroarylamide and urea derivatives as inhibitors of acyl coenzyme A: cholesterol acyl transferase | PFIZER (US) | 1995-04-26 | — | — | EP | disclosed |
| US-5362878-A | Intermediates for making N-aryl and N-heteroarylamide and urea derivatives as inhibitors of acyl coenzyme A: cholesterol acyl transferase (ACAT) | PFIZER INC. (US) | 1994-11-08 | — | — | US | disclosed |
| EP-0418071-A2 | New N-aryl and N-heteroarylamide and urea derivatives as inhibitors of acyl coenzyme A: cholesterol acyl transferase | PFIZER INC. (US) | 1991-03-20 | — | — | EP | disclosed |