Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC22A1 | O15245 | 1/20 | 0.48 |
| ▸ | DNM1 | Q05193 | 2/20 | 0.37 |
| ▸ | FFAR3 | O14843 | 2/20 | 0.35 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.35 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.35 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.35 |
| ▸ | BBOX1 | O75936 | 1/20 | 0.34 |
| ▸ | CES2 | O00748 | 1/20 | 0.33 |
| ▸ | CES1 | P23141 | 1/20 | 0.33 |
| ▸ | PSMD14 | O00487 | 2/20 | 0.32 |
| ▸ | PLA2G1B | P04054 | 2/20 | 0.32 |
| ▸ | MMP2 | P08253 | 2/20 | 0.32 |
| ▸ | ATG4B | Q9Y4P1 | 2/20 | 0.32 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.32 |
| ▸ | RAD52 | P43351 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bicarbonate SCHEMBL8857005 | 0.93 | SLC22A1 (0.50) | SLC22A1DNM1FFAR3HDAC3HDAC1 | |
| Bicarbonate SCHEMBL8857089 | 0.91 | SLC22A1 (0.48) | SLC22A1DNM1FFAR3HDAC3HDAC1 | |
| Bicarbonate SCHEMBL8857010 | 0.90 | SLC22A1 (0.53) | SLC22A1DNM1PSMD14PLA2G1BMMP2 | |
| Tetrapropylammonium SCHEMBL108600 | 0.90 | SLC22A1 (0.59) | SLC22A1FFAR3HDAC3HDAC1HDAC2 | |
| Bicarbonate SCHEMBL30507730 | 0.86 | SLC22A1 (0.52) | SLC22A1DNM1 | |
| Bicarbonate SCHEMBL8856951 | 0.86 | SLC22A1 (0.52) | SLC22A1DNM1CES2CES1 | |
| Fumaric Acid SCHEMBL2354659 | 0.85 | SLC22A1 (0.42) | SLC22A1DNM1FFAR3HDAC3HDAC1 | |
| Fumaric Acid SCHEMBL2354666 | 0.85 | SLC22A1 (0.42) | SLC22A1DNM1FFAR3HDAC3HDAC1 | |
| Fumaric Acid SCHEMBL5143517 | 0.85 | SLC22A1 (0.42) | SLC22A1DNM1FFAR3HDAC3HDAC1 | |
| SCHEMBL14839961 | 0.84 | SLC22A1 (0.67) | SLC22A1DNM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5693599-A | Flux washing agent | MITSUBISHI GAS CHEMICAL COMPANY, INC. (JP) | 1997-12-02 | — | — | US | claimed |
| US-5693599-A | Flux washing agent | MITSUBISHI GAS CHEMICAL COMPANY, INC. (JP) | 1997-12-02 | — | — | US | disclosed |