Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TUBB1 | Q9H4B7 | 2/20 | 0.44 |
| ▸ | CTSL | P07711 | 1/20 | 0.32 |
| ▸ | CTSB | P07858 | 1/20 | 0.32 |
| ▸ | CTSS | P25774 | 1/20 | 0.32 |
| ▸ | CTSK | P43235 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL59366 | 1.00 | TUBB1 (0.44) | TUBB1CTSLCTSBCTSSCTSK | |
| SCHEMBL59360 | 0.90 | TUBB1 (0.38) | TUBB1CTSLCTSBCTSSCTSK | |
| SCHEMBL59190 | 0.89 | TUBB1 (0.54) | TUBB1 | |
| SCHEMBL58506 | 0.81 | TUBB1 (0.43) | TUBB1 | |
| SCHEMBL59371 | 0.80 | TUBB1 (0.46) | TUBB1 | |
| SCHEMBL58912 | 0.77 | TUBB1 (0.42) | TUBB1 | |
| SCHEMBL6800265 | 0.77 | TUBB1 (0.68) | TUBB1CTSLCTSBCTSSCTSK | |
| SCHEMBL6671030 | 0.77 | TUBB1 (0.68) | TUBB1CTSLCTSBCTSSCTSK | |
| SCHEMBL60095 | 0.77 | TUBB1 (0.43) | TUBB1 | |
| SCHEMBL6801150 | 0.76 | TUBB1 (0.63) | TUBB1CTSLCTSBCTSSCTSK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2374454-A1 | Hemiasterlin derivatives and uses thereof in the treatment of cancer | Eisai R&D Management Co., Ltd. (JP) | 2011-10-12 | — | — | EP | disclosed |