Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Amphetamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 known ✓ | P23975 | 4/20 | 1.00 |
| ▸ | SLC6A3 known ✓ | Q01959 | 2/20 | 1.00 |
| ▸ | TAAR1 | Q96RJ0 | 4/20 | 1.00 |
| ▸ | SLC6A4 | P31645 | 3/20 | 1.00 |
| ▸ | MAOA | P21397 | 1/20 | 1.00 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 1.00 |
| ▸ | CYP2A6 | P11509 | 1/20 | 1.00 |
| ▸ | ADORA2A | P29274 | 1/20 | 1.00 |
| ▸ | ADORA1 | P30542 | 1/20 | 1.00 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.67 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.64 |
| ▸ | PNMT | P11086 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Levamfetamine SCHEMBL2636 | 1.00 | SLC6A2 (1.00) | SLC6A2TAAR1SLC6A4SLC6A3MAOA | |
| Amphetamine SCHEMBL1560962 | 1.00 | SLC6A2 (1.00) | SLC6A2TAAR1SLC6A4SLC6A3MAOA | |
| Amphetamine SCHEMBL13747797 | 1.00 | SLC6A2 (1.00) | SLC6A2TAAR1SLC6A4SLC6A3MAOA | |
| Amphetamine SCHEMBL13747801 | 1.00 | SLC6A2 (1.00) | SLC6A2TAAR1SLC6A4SLC6A3MAOA | |
| Dextroamphetamine SCHEMBL8859 | 1.00 | SLC6A2 (1.00) | SLC6A2TAAR1SLC6A4SLC6A3MAOA | |
| Amphetamine SCHEMBL15094242 | 1.00 | SLC6A2 (1.00) | SLC6A2TAAR1SLC6A4SLC6A3MAOA | |
| Levamfetamine SCHEMBL9673275 | 1.00 | SLC6A2 (1.00) | SLC6A2TAAR1SLC6A4SLC6A3MAOA | |
| Amphetamine SCHEMBL13746679 | 1.00 | SLC6A2 (1.00) | SLC6A2TAAR1SLC6A4SLC6A3MAOA | |
| Amphetamine SCHEMBL910141 | 1.00 | SLC6A2 (1.00) | SLC6A2TAAR1SLC6A4SLC6A3MAOA | |
| Amphetamine SCHEMBL4781164 | 1.00 | SLC6A2 (1.00) | SLC6A2TAAR1SLC6A4SLC6A3MAOA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 77264 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20260144773-A1 | METHODS OF REDUCING PHYSICAL DEPENDENCE TO NEUROPSYCHIATRIC TREATMENTS | SUMITOMO PHARMA AMERICA, INC. (US) | 2026-05-28 | — | — | US | claimed |
| EP-4747639-A2 | BETA-GALACTOSIDASE ENZYME-BASED IMMUNOASSAY | Abbott Diagnostics Scarborough, Inc. (US) | 2026-05-27 | — | — | EP | claimed |
| CN-122094963-A | Cardioprotective lipids and methods of use | — | 2026-05-26 | — | — | CN | claimed |
| CN-122094679-A | Methods of treating sleep disorders using triple reuptake inhibitors | — | 2026-05-26 | — | — | CN | claimed |
| CN-122072257-A | Method for rapidly detecting poison in blood | 中国科学院大连化学物理研究所 | 2026-05-22 | — | — | CN | claimed |
| US-20260141998-A1 | METHOD FOR TRACKING, VERIFYING, AND AUTHENTICATING MULTI-STAGE CHAIN OF CUSTODY | Courtfact, LLC (US) | 2026-05-21 | — | — | US | claimed |
| WO-2026106917-A1 | EDIBLE TRANSMUCOSAL DRUG DELIVERY METHOD USING AN INTERMEDIATE CAPSULE AS A TEMPORARY VESSEL | BioPhysics Pharma, Inc. (US) | 2026-05-21 | — | — | WO | claimed |
| EP-3934635-B1 | COMPOSITIONS COMPRISING ENZYME-CLEAVABLE AMPHETAMINE PRODRUGS AND INHIBITORS THEREOF | ENSYSCE BIOSCIENCES INC (US) | 2026-05-20 | — | — | EP | claimed |
| EP-3956283-B1 | PROCESS OF PREPARING POLYOL-BASED ESTERS OF ACYL-CAPPED HYDROXY CARBOXYLIC ACIDS | KETOLIPIX THERAPEUTICS GMBH (DE) | 2026-05-20 | — | — | EP | claimed |
| CN-121431735-B | Characterization method of molecular weight and molecular weight distribution of crystalline polyaryletherketone | 吉林大学 | 2026-05-19 | — | — | CN | claimed |
| US-4117161-A | METHOD OF PHARMACOLOGICALLY TREATING DRUG ADDICTION WITH ALPHA-METHYL-PARA-TYROSINE | POZUELO JOSE | 1978-09-26 | — | — | US | claimed |
| US-4097586-A | Immunochemical assay method | BIOLOGICAL DEVELOPMENTS, INC. (US) | 1978-06-27 | — | — | US | claimed |
| US-4067774-A | Compounds for enzyme amplification assay | SYVA COMPANY (US) | 1978-01-10 | — | — | US | claimed |
| US-4066747-A | Polymeric orthoesters housing beneficial drug for controlled release therefrom | ALZA CORPORATION (US) | 1978-01-03 | — | — | US | claimed |
| US-4022878-A | NATIVE HOMOLOGOUS HAPTEN OR ANTIGEN | BIOLOGICAL DEVELOPMENTS, INC. (US) | 1977-05-10 | — | — | US | claimed |
| US-4016146-A | Phenethylamine antigenic conjugates, their preparation, antibodies, and use | BIOLOGICAL DEVELOPMENTS, INC. (US) | 1977-04-05 | — | — | US | claimed |
| US-4011046-A | LIQUID CRYSTAL QUANTITATIVE ANALYSIS METHOD FOR OPTICALLY ACTIVE COMPOUNDS | TEMPLE UNIVERSITY (US) | 1977-03-08 | — | — | US | claimed |
| US-3996344-A | Phenethylamine antigenic conjugates, their preparation, antibodies and use | BIOLOGICAL DEVELOPMENTS, INC. (US) | 1976-12-07 | — | — | US | claimed |
| US-3968245-A | Sympathomimetic topical and percutaneous administration with halogenated promoters | ALZA CORPORATION (US) | 1976-07-06 | — | — | US | claimed |
| US-3952091-A | Simultaneous multiple radioimmunoassay | HOFFMANN-LA ROCHE INC. (US) | 1976-04-20 | — | — | US | claimed |