Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 19/20 | 0.62 |
| ▸ | MAPK13 | O15264 | 18/20 | 0.62 |
| ▸ | MAPK12 | P53778 | 18/20 | 0.62 |
| ▸ | MAPK11 | Q15759 | 18/20 | 0.62 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.46 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.46 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.46 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.46 |
| ▸ | CDC42BPA | Q5VT25 | 1/20 | 0.46 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.46 |
| ▸ | MAP4K5 | Q9Y4K4 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8860439 | 0.99 | MAPK14 (0.61) | MAPK14MAPK13MAPK12MAPK11MAP4K4 | |
| SCHEMBL8860264 | 0.90 | MAPK14 (0.59) | MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL8860326 | 0.78 | MAPK14 (0.67) | MAPK14MAPK13MAPK12MAPK11MAP4K4 | |
| SCHEMBL4587383 | 0.78 | MAPK14 (1.00) | MAPK14MAPK13MAPK12MAPK11MAP4K4 | |
| SCHEMBL6583564 | 0.76 | MAPK14 (0.68) | MAPK14MAPK13MAPK12MAPK11MAP4K4 | |
| SCHEMBL6585407 | 0.76 | MAPK14 (0.68) | MAPK14MAPK13MAPK12MAPK11MAP4K4 | |
| SCHEMBL4915403 | 0.76 | MAPK14 (0.64) | MAPK14MAPK13MAPK12MAPK11MAP4K4 | |
| SCHEMBL8860479 | 0.75 | MAPK13 (0.53) | MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL8860478 | 0.73 | MAPK14 (0.60) | MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL7607069 | 0.72 | MAPK14 (0.63) | MAPK14MAPK13MAPK12MAPK11MAP4K4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5670527-A | CYTOKINE INHIBITORS USEFUL IN TREATING ASTHMA, OSTEOPOROSIS, ARTHRITIS, INFLAMMATION, SEPSIS, CARDIOVASCULAR DISORDERS, DIABETES, MULTIPLE SCLEROSIS, SKIN DISORDERS | SMITHKLINE BEECHAM CORPORATION (US) | 1997-09-23 | — | — | US | disclosed |