Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALK | Q9UM73 | 12/20 | 0.61 |
| ▸ | MET | P08581 | 1/20 | 0.61 |
| ▸ | INSR | P06213 | 6/20 | 0.58 |
| ▸ | KDR | P35968 | 8/20 | 0.56 |
| ▸ | AURKB | Q96GD4 | 8/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL886330 | 1.00 | ALK (0.61) | ALKMETINSRKDRAURKB | |
| SCHEMBL9949272 | 1.00 | ALK (0.61) | ALKMETINSRKDRAURKB | |
| SCHEMBL16966235 | 0.91 | ALK (0.51) | ALKMETINSRKDRAURKB | |
| SCHEMBL9949634 | 0.90 | ALK (0.62) | ALKMETINSRKDRAURKB | |
| SCHEMBL9949630 | 0.90 | ALK (0.62) | ALKMETINSRKDRAURKB | |
| SCHEMBL886049 | 0.86 | ALK (0.68) | ALKMETINSRKDRAURKB | |
| SCHEMBL886048 | 0.86 | ALK (0.68) | ALKMETINSRKDRAURKB | |
| SCHEMBL2061954 | 0.86 | ALK (0.68) | ALKMETINSRKDRAURKB | |
| SCHEMBL2943198 | 0.83 | ALK (0.65) | ALKMETINSRKDRAURKB | |
| SCHEMBL2062432 | 0.82 | ALK (0.68) | ALKMETINSRKDRAURKB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2222647-A1 | FUSED BICYCLIC DERIVATIVES OF 2,4-DIAMINOPYRIMIDINE AS ALK AND C-MET INHIBITORS | Cephalon, Inc. (US) | 2010-09-01 | — | — | EP | claimed |
| WO-2008051547-A1 | FUSED BICYCLIC DERIVATIVES OF 2,4-DIAMINOPYRIMIDINE AS ALK AND C-MET INHIBITORS | CEPHALON, INC. (US) | 2008-05-02 | — | — | WO | claimed |
| EP-2222647-A1 | FUSED BICYCLIC DERIVATIVES OF 2,4-DIAMINOPYRIMIDINE AS ALK AND C-MET INHIBITORS | Cephalon, Inc. (US) | 2010-09-01 | — | — | EP | disclosed |
| WO-2008051547-A1 | FUSED BICYCLIC DERIVATIVES OF 2,4-DIAMINOPYRIMIDINE AS ALK AND C-MET INHIBITORS | CEPHALON, INC. (US) | 2008-05-02 | — | — | WO | disclosed |