Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 | P11229 | 14/20 | 0.76 |
| ▸ | CHRM2 | P08172 | 5/20 | 0.76 |
| ▸ | CHRM4 | P08173 | 5/20 | 0.76 |
| ▸ | CHRM3 | P20309 | 4/20 | 0.76 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.62 |
| ▸ | CHRM5 | P08912 | 3/20 | 0.61 |
| ▸ | DRD2 | P14416 | 3/20 | 0.61 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.61 |
| ▸ | HTR2C | P28335 | 1/20 | 0.61 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.61 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.61 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.60 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.60 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.60 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8863420 | 1.00 | CHRM1 (0.76) | CHRM1CHRM2CHRM4CHRM3SLC18A3 | |
| SCHEMBL8863517 | 1.00 | CHRM1 (0.76) | CHRM1CHRM2CHRM4CHRM3SLC18A3 | |
| SCHEMBL2604448 | 0.92 | CHRM1 (0.62) | CHRM1CHRM2CHRM4CHRM3SLC18A3 | |
| SCHEMBL2604450 | 0.92 | CHRM1 (0.62) | CHRM1CHRM2CHRM4CHRM3SLC18A3 | |
| SCHEMBL22605478 | 0.92 | CHRM1 (0.62) | CHRM1CHRM2CHRM4CHRM3SLC18A3 | |
| SCHEMBL342295 | 0.92 | CHRM1 (0.62) | CHRM1CHRM2CHRM4CHRM3SLC18A3 | |
| Hydrochloric Acid SCHEMBL15273446 | 0.90 | CHRM1 (0.60) | CHRM1CHRM2CHRM4CHRM3SLC18A3 | |
| Hydrochloric Acid SCHEMBL16444395 | 0.90 | CHRM1 (0.60) | CHRM1CHRM2CHRM4CHRM3SLC18A3 | |
| SCHEMBL3895786 | 0.88 | CHRM1 (0.92) | CHRM1CHRM2CHRM4CHRM3SLC18A3 | |
| SCHEMBL13074241 | 0.87 | CHRM1 (0.76) | CHRM1CHRM2CHRM4CHRM3SLC18A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5691323-A | BENZIMIDAZOL-2-ONES | MERCK & CO., INC. (US) | 1997-11-25 | — | — | US | disclosed |
| US-5574044-A | BENZIMIDAZOL-2-ONE COMPOUNDS FOR TREATMENT OF MYOPIA | MERCK & CO., INC. (US) | 1996-11-12 | — | — | US | disclosed |
| WO-1996013262-A1 | MUSCARINE ANTAGONISTS | MERCK & CO., INC. (US) | 1996-05-09 | — | — | WO | disclosed |