Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM1A | O60341 | 2/20 | 0.57 |
| ▸ | MAOB | P27338 | 2/20 | 0.57 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.48 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.46 |
| ▸ | MAOA | P21397 | 1/20 | 0.45 |
| ▸ | TLR2 | O60603 | 1/20 | 0.42 |
| ▸ | TLR1 | Q15399 | 1/20 | 0.42 |
| ▸ | SSTR4 | P31391 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.42 |
| ▸ | FPR1 | P21462 | 2/20 | 0.41 |
| ▸ | FPR2 | P25090 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.41 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19459195 | 1.00 | KDM1A (0.57) | KDM1AMAOBEPHX2ROCK2MAOA | |
| SCHEMBL15717069 | 1.00 | KDM1A (0.57) | KDM1AMAOBEPHX2ROCK2MAOA | |
| SCHEMBL15717067 | 1.00 | KDM1A (0.57) | KDM1AMAOBEPHX2ROCK2MAOA | |
| SCHEMBL15717065 | 1.00 | KDM1A (0.57) | KDM1AMAOBEPHX2ROCK2MAOA | |
| SCHEMBL7826671 | 0.88 | KDM1A (0.57) | KDM1AMAOBEPHX2MAOASSTR4 | |
| SCHEMBL4509886 | 0.88 | KDM1A (0.50) | KDM1AMAOBEPHX2ROCK2MAOA | |
| SCHEMBL23369468 | 0.85 | AKT1 (0.44) | KDM1AMAOBEPHX2 | |
| SCHEMBL21935980 | 0.85 | AKT1 (0.44) | KDM1AMAOBEPHX2 | |
| SCHEMBL21622316 | 0.85 | AKT1 (0.44) | KDM1AMAOBEPHX2 | |
| SCHEMBL19181167 | 0.85 | AKT1 (0.44) | KDM1AMAOBEPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5668164-A | Process for synthesis of chiral cis-and trans-3-amino-4 substituted pyrrolidine compounds | ABBOTT LABORATORIES (US) | 1997-09-16 | — | — | US | disclosed |
| US-5618949-A | Process for synthesis of chiral cis- and trans-3-amino-4-substituted pyrrolidine compounds | ABBOTT LABORATORIES (US) | 1997-04-08 | — | — | US | disclosed |