Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | P4HTM | Q9NXG6 | 2/20 | 0.50 |
| ▸ | SGMS1 | Q86VZ5 | 5/20 | 0.49 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.48 |
| ▸ | BCL2L1 | Q07817 | 4/20 | 0.48 |
| ▸ | MCL1 | Q07820 | 4/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8869118 | 0.92 | PTPN1 (0.51) | POLBP4HTMSGMS1PTPN1BCL2L1 | |
| SCHEMBL8868572 | 0.92 | POLB (0.54) | POLBP4HTMSGMS1PTPN1BCL2L1 | |
| SCHEMBL9139307 | 0.92 | P4HTM (0.61) | POLBP4HTMSGMS1PTPN1BCL2L1 | |
| SCHEMBL8867695 | 0.91 | P4HTM (0.48) | POLBP4HTMSGMS1PTPN1ALDH1A1 | |
| SCHEMBL8870006 | 0.90 | POLB (0.48) | POLBP4HTMSGMS1PTPN1BCL2L1 | |
| SCHEMBL8868015 | 0.90 | POLB (0.52) | POLBP4HTMSGMS1PTPN1BCL2L1 | |
| SCHEMBL9137438 | 0.89 | PTPN1 (0.53) | POLBP4HTMSGMS1PTPN1BCL2L1 | |
| SCHEMBL7867954 | 0.89 | POLB (0.50) | POLBP4HTMSGMS1PTPN1BCL2L1 | |
| SCHEMBL8867954 | 0.89 | POLB (0.47) | POLBP4HTMSGMS1PTPN1BCL2L1 | |
| SCHEMBL8869732 | 0.88 | P4HTM (0.53) | P4HTMLMNANPC1RAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5607954-A | Sulfonamido- and sulfonamidocarbonylpyridine-2-carboxamides and their pyridine-n-oxides, process for their preparation and their use as pharmaceuticals | HOECHST AKTIENGESELLSCHAFT (DE) | 1997-03-04 | — | — | US | disclosed |