Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNA5 | P22460 | 14/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 6/20 | 0.45 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.35 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.35 |
| ▸ | GRM4 | Q14833 | 2/20 | 0.35 |
| ▸ | METAP2 | P50579 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL884542 | 1.00 | KCNA5 (0.45) | KCNA5KCNH2PDE10ASLC6A2SLC6A4 | |
| SCHEMBL2063860 | 1.00 | KCNA5 (0.45) | KCNA5KCNH2PDE10ASLC6A2SLC6A4 | |
| SCHEMBL884679 | 0.94 | KCNA5 (0.43) | KCNA5KCNH2SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL884941 | 0.84 | KCNA5 (0.46) | KCNA5KCNH2PDE10A | |
| SCHEMBL884458 | 0.84 | KCNA5 (0.45) | KCNA5KCNH2PDE10ASLC6A2SLC6A4 | |
| SCHEMBL886764 | 0.84 | KCNA5 (0.45) | KCNA5KCNH2PDE10ASLC6A2SLC6A4 | |
| SCHEMBL884946 | 0.83 | KCNA5 (0.41) | KCNA5KCNH2PDE10ASLC6A2SLC6A4 | |
| SCHEMBL884635 | 0.83 | KCNA5 (0.51) | KCNA5KCNH2SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL884666 | 0.82 | KCNA5 (0.50) | KCNA5KCNH2SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL884510 | 0.80 | KCNA5 (0.48) | KCNA5KCNH2SLC6A2SLC6A4SLC6A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1940406-A2 | POTASSIUM CHANNEL INHIBITORS | Merck and Co., Inc. (US) | 2008-07-09 | — | — | EP | claimed |
| WO-2007050348-A2 | POTASSIUM CHANNEL INHIBITORS | MERCK & CO., INC. (US) | 2007-05-03 | — | — | WO | claimed |