Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P4HTM | Q9NXG6 | 1/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.56 |
| ▸ | MEN1 | O00255 | 3/20 | 0.56 |
| ▸ | HPGD | P15428 | 2/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | PPARA | Q07869 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8868352 | 0.93 | P4HTM (0.61) | P4HTMKMT2AMEN1SMN1; SMN2MAPT | |
| SCHEMBL8870517 | 0.91 | PPARA (0.50) | P4HTMKMT2AMEN1SMN1; SMN2MAPT | |
| SCHEMBL8867904 | 0.90 | MAPT (0.51) | P4HTMKMT2AMEN1SMN1; SMN2MAPT | |
| SCHEMBL8868930 | 0.90 | P4HTM (0.51) | P4HTMKMT2AMEN1SMN1; SMN2MAPT | |
| SCHEMBL8870251 | 0.90 | NPC1 (0.52) | P4HTMKMT2AMEN1SMN1; SMN2MAPT | |
| SCHEMBL8868796 | 0.89 | TSHR (0.56) | P4HTMKMT2AMAPTALDH1A1RAB9A | |
| SCHEMBL8868858 | 0.89 | CA1 (0.56) | KMT2AMEN1SMN1; SMN2MAPTALDH1A1 | |
| SCHEMBL7869444 | 0.89 | KMT2A (0.53) | P4HTMKMT2AMEN1HPGDSMN1; SMN2 | |
| SCHEMBL8869631 | 0.89 | P4HTM (0.53) | P4HTMKMT2AHPGDSMN1; SMN2MAPT | |
| SCHEMBL8868196 | 0.88 | P4HTM (0.53) | P4HTMKMT2AMEN1HPGDSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5607954-A | Sulfonamido- and sulfonamidocarbonylpyridine-2-carboxamides and their pyridine-n-oxides, process for their preparation and their use as pharmaceuticals | HOECHST AKTIENGESELLSCHAFT (DE) | 1997-03-04 | — | — | US | disclosed |