Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.62 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.51 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.51 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.51 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.51 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.51 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.51 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.51 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.51 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.51 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.51 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.51 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.51 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.51 |
| ▸ | NPC1 | O15118 | 1/20 | 0.51 |
| ▸ | CASP3 | P42574 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8867973 | 1.00 | TDP1 (0.62) | TDP1LMNASMN1; SMN2HDAC3MAPK1 | |
| SCHEMBL8867570 | 1.00 | TDP1 (0.62) | TDP1LMNASMN1; SMN2HDAC3MAPK1 | |
| SCHEMBL8868323 | 0.95 | TDP1 (0.60) | TDP1LMNAHDAC1HDAC2FFAR1 | |
| SCHEMBL9176914 | 0.94 | TDP1 (0.72) | TDP1LMNASMN1; SMN2FFAR1ALOX5 | |
| SCHEMBL12446326 | 0.92 | TDP1 (0.72) | TDP1LMNASMN1; SMN2HDAC3MAPK1 | |
| SCHEMBL8868087 | 0.90 | TDP1 (0.66) | TDP1LMNASMN1; SMN2HDAC3MAPK1 | |
| SCHEMBL19643833 | 0.90 | TDP1 (0.70) | TDP1LMNASMN1; SMN2HDAC3MAPK1 | |
| SCHEMBL1788500 | 0.89 | TDP1 (0.68) | TDP1LMNASMN1; SMN2HDAC1HDAC2 | |
| SCHEMBL7781081 | 0.89 | TDP1 (0.68) | TDP1LMNASMN1; SMN2HDAC1HDAC2 | |
| SCHEMBL31657266 | 0.89 | TDP1 (0.72) | TDP1LMNASMN1; SMN2HDAC3MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5599966-A | SUITABLE FOR TREATMENT OF DISEASES OF RESPIRATORY PASSAGES | BYK NEDERLAND BV (NL) | 1997-02-04 | — | — | US | disclosed |
| EP-0664788-A1 | SUBSTITUTED ETHANOLAMINE ESTERS | Byk Nederland BV (NL) | 1995-08-02 | — | — | EP | disclosed |
| WO-1994008945-A1 | SUBSTITUTED ETHANOLAMINE ESTERS | BYK NEDERLAND BV (NL) | 1994-04-28 | — | — | WO | disclosed |