Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 6/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | PTGDR | Q13258 | 2/20 | 0.41 |
| ▸ | PTGDR2 | Q9Y5Y4 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 4/20 | 0.41 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8869043 | 0.96 | HPGD (0.44) | HPGDSMN1; SMN2RAB9ANPC1ALDH1A1 | |
| SCHEMBL8869219 | 0.94 | HPGD (0.43) | HPGDSMN1; SMN2RAB9ANPC1ALDH1A1 | |
| SCHEMBL9139272 | 0.93 | HPGD (0.44) | HPGDSMN1; SMN2RAB9ANPC1ALDH1A1 | |
| SCHEMBL8868908 | 0.92 | HPGD (0.42) | HPGDSMN1; SMN2RAB9ANPC1ALDH1A1 | |
| SCHEMBL9143084 | 0.90 | HPGD (0.41) | HPGDSMN1; SMN2RAB9ANPC1ALDH1A1 | |
| SCHEMBL9143088 | 0.90 | KMT2A (0.43) | HPGDSMN1; SMN2RAB9ANPC1ALDH1A1 | |
| SCHEMBL7869470 | 0.89 | PTGDR (0.44) | HPGDSMN1; SMN2RAB9ANPC1ALDH1A1 | |
| SCHEMBL8869968 | 0.88 | HPGD (0.39) | HPGDSMN1; SMN2RAB9ANPC1ALDH1A1 | |
| SCHEMBL8868727 | 0.88 | SMN1; SMN2 (0.46) | HPGDSMN1; SMN2RAB9ANPC1ALDH1A1 | |
| SCHEMBL8869975 | 0.88 | EGLN1 (0.44) | HPGDSMN1; SMN2RAB9ANPC1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5607954-A | Sulfonamido- and sulfonamidocarbonylpyridine-2-carboxamides and their pyridine-n-oxides, process for their preparation and their use as pharmaceuticals | HOECHST AKTIENGESELLSCHAFT (DE) | 1997-03-04 | — | — | US | disclosed |