Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 2/20 | 0.57 |
| ▸ | FLT1 | P17948 | 1/20 | 0.53 |
| ▸ | FLT4 | P35916 | 1/20 | 0.53 |
| ▸ | KDR | P35968 | 1/20 | 0.53 |
| ▸ | MCHR1 | Q99705 | 2/20 | 0.52 |
| ▸ | NPC1 | O15118 | 4/20 | 0.51 |
| ▸ | RAB9A | P51151 | 4/20 | 0.51 |
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.51 |
| ▸ | GFER | P55789 | 1/20 | 0.51 |
| ▸ | PPARA | Q07869 | 1/20 | 0.51 |
| ▸ | CA12 | O43570 | 2/20 | 0.50 |
| ▸ | CA1 | P00915 | 2/20 | 0.50 |
| ▸ | CA2 | P00918 | 2/20 | 0.50 |
| ▸ | CA9 | Q16790 | 2/20 | 0.50 |
| ▸ | P4HTM | Q9NXG6 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8868351 | 1.00 | EGFR (0.57) | EGFRFLT1FLT4KDRMCHR1 | |
| SCHEMBL8867818 | 0.92 | P4HTM (0.57) | FLT1FLT4KDRMCHR1NPC1 | |
| SCHEMBL9141303 | 0.92 | P4HTM (0.60) | EGFRFLT1FLT4KDRMCHR1 | |
| SCHEMBL9139923 | 0.92 | P4HTM (0.60) | EGFRFLT1FLT4KDRMCHR1 | |
| SCHEMBL8869113 | 0.91 | EGFR (0.54) | EGFRFLT1FLT4KDRNPC1 | |
| SCHEMBL8869154 | 0.91 | MAPT (0.54) | EGFRNPC1RAB9AMAPTSMN1; SMN2 | |
| SCHEMBL8867656 | 0.91 | MAPT (0.54) | EGFRNPC1RAB9AMAPTSMN1; SMN2 | |
| SCHEMBL8869159 | 0.91 | P4HTM (0.58) | MCHR1NPC1RAB9AMAPTSMN1; SMN2 | |
| SCHEMBL8869577 | 0.90 | EGFR (0.53) | EGFRFLT1FLT4KDRNPC1 | |
| SCHEMBL8869604 | 0.90 | EGFR (0.53) | EGFRFLT1FLT4KDRNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5607954-A | Sulfonamido- and sulfonamidocarbonylpyridine-2-carboxamides and their pyridine-n-oxides, process for their preparation and their use as pharmaceuticals | HOECHST AKTIENGESELLSCHAFT (DE) | 1997-03-04 | — | — | US | disclosed |