Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARA | Q07869 | 3/20 | 0.53 |
| ▸ | EGFR | P00533 | 1/20 | 0.51 |
| ▸ | NPC1 | O15118 | 2/20 | 0.48 |
| ▸ | RAB9A | P51151 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | P4HTM | Q9NXG6 | 1/20 | 0.48 |
| ▸ | FLT1 | P17948 | 1/20 | 0.47 |
| ▸ | FLT4 | P35916 | 1/20 | 0.47 |
| ▸ | KDR | P35968 | 1/20 | 0.47 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | GAA | P10253 | 2/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | GFER | P55789 | 1/20 | 0.46 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.46 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8869066 | 1.00 | PPARA (0.53) | PPARAEGFRNPC1RAB9AMEN1 | |
| SCHEMBL8868236 | 0.93 | P4HTM (0.51) | PPARANPC1RAB9AMEN1KMT2A | |
| SCHEMBL8869126 | 0.92 | PPARA (0.51) | PPARAEGFRNPC1RAB9AMEN1 | |
| SCHEMBL8868460 | 0.92 | MAPT (0.52) | PPARANPC1RAB9AMEN1KMT2A | |
| SCHEMBL8868766 | 0.92 | P4HTM (0.59) | PPARANPC1RAB9AMEN1KMT2A | |
| SCHEMBL8868685 | 0.92 | MAPT (0.52) | PPARANPC1RAB9AMEN1KMT2A | |
| SCHEMBL8869489 | 0.91 | PPARA (0.50) | PPARAEGFRNPC1RAB9AMEN1 | |
| SCHEMBL8869237 | 0.91 | PPARA (0.50) | PPARAEGFRNPC1RAB9AMEN1 | |
| SCHEMBL8868562 | 0.91 | P4HTM (0.51) | PPARANPC1RAB9AMEN1KMT2A | |
| SCHEMBL8869577 | 0.91 | EGFR (0.53) | PPARAEGFRNPC1RAB9AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5607954-A | Sulfonamido- and sulfonamidocarbonylpyridine-2-carboxamides and their pyridine-n-oxides, process for their preparation and their use as pharmaceuticals | HOECHST AKTIENGESELLSCHAFT (DE) | 1997-03-04 | — | — | US | disclosed |