Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 3/20 | 0.65 |
| ▸ | MAPT | P10636 | 5/20 | 0.59 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.59 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.59 |
| ▸ | RELA | Q04206 | 2/20 | 0.59 |
| ▸ | PKM | P14618 | 2/20 | 0.59 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.50 |
| ▸ | MIF | P14174 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 3/20 | 0.48 |
| ▸ | RAB9A | P51151 | 3/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | MASP2 | O00187 | 1/20 | 0.47 |
| ▸ | F2 | P00734 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | MAOB | P27338 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | TYR | P14679 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8870164 | 0.89 | CYP19A1 (0.64) | CYP19A1MAPTNFKB1NFKB2RELA | |
| SCHEMBL8870161 | 0.89 | CYP19A1 (0.64) | CYP19A1MAPTNFKB1NFKB2RELA | |
| SCHEMBL8869603 | 0.81 | MAPT (0.63) | CYP19A1MAPTNFKB1NFKB2RELA | |
| SCHEMBL6822432 | 0.79 | CYP19A1 (1.00) | CYP19A1MAPTPKMMIFALDH1A1 | |
| SCHEMBL6822430 | 0.79 | CYP19A1 (1.00) | CYP19A1MAPTPKMMIFALDH1A1 | |
| SCHEMBL7509263 | 0.77 | CYP19A1 (0.64) | CYP19A1MAPTKDM4EALDH1A1KMT2A | |
| SCHEMBL30832110 | 0.77 | CYP19A1 (0.75) | CYP19A1MAPTMIFNPC1RAB9A | |
| SCHEMBL23345445 | 0.76 | NR1I2 (0.86) | MAPTNFKB1NFKB2RELAPKM | |
| SCHEMBL28017988 | 0.76 | NR1I2 (0.86) | MAPTNFKB1NFKB2RELAPKM | |
| SCHEMBL7125573 | 0.75 | CYP19A1 (0.61) | CYP19A1MAPTKDM4EALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5607928-A | Carbapenem derivatives containing a bicyclic ketone substituent and their use as anti-infectives | ZENECA LIMITED (GB) | 1997-03-04 | — | — | US | disclosed |
| EP-0695753-A1 | Carbapenem derivatives containing a bicyclic substituent, process for their preparation, and their use | ZENECA LIMITED (GB) | 1996-02-07 | — | — | EP | disclosed |