Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METAP1 | P53582 | 5/20 | 0.50 |
| ▸ | ACHE | P22303 | 1/20 | 0.42 |
| ▸ | CA2 | P00918 | 1/20 | 0.37 |
| ▸ | CA5A | P35218 | 1/20 | 0.37 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.37 |
| ▸ | THRA | P10827 | 1/20 | 0.35 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8595436 | 1.00 | METAP1 (0.50) | METAP1ACHECA2CA5ACYP19A1 | |
| SCHEMBL8874203 | 0.89 | METAP1 (0.46) | METAP1ACHECA2CA5ACYP19A1 | |
| SCHEMBL8595459 | 0.89 | METAP1 (0.46) | METAP1ACHECA2CA5ACYP19A1 | |
| SCHEMBL8595460 | 0.89 | METAP1 (0.46) | METAP1ACHECA2CA5ACYP19A1 | |
| SCHEMBL8598724 | 0.84 | METAP1 (0.69) | METAP1ACHECYP19A1 | |
| SCHEMBL8874562 | 0.84 | METAP1 (0.69) | METAP1ACHECYP19A1 | |
| SCHEMBL8874791 | 0.82 | METAP1 (0.52) | METAP1ACHECYP19A1THRATHRB | |
| SCHEMBL8600859 | 0.82 | METAP1 (0.52) | METAP1ACHECYP19A1THRATHRB | |
| SCHEMBL8595906 | 0.79 | METAP1 (0.49) | METAP1ACHECYP19A1THRATHRB | |
| SCHEMBL8874602 | 0.79 | METAP1 (0.49) | METAP1ACHECYP19A1THRATHRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5646173-A | ANTISEROTONINE AGENTS; CENTRAL NERVOUS SYSTEM DISORDERS; ANTIDEPRESSANTS | HOFFMANN-LA ROCHE INC. (US) | 1997-07-08 | — | — | US | disclosed |