Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLG | P00747 | 1/20 | 0.34 |
| ▸ | HTR1D | P28221 | 5/20 | 0.33 |
| ▸ | HTR1B | P28222 | 5/20 | 0.33 |
| ▸ | HTR1A | P08908 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | HTR2A | P28223 | 1/20 | 0.33 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.33 |
| ▸ | HTR1F | P30939 | 1/20 | 0.32 |
| ▸ | IRAK4 | Q9NWZ3 | 3/20 | 0.31 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.30 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.30 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.30 |
| ▸ | PDCD1LG2 | Q9BQ51 | 2/20 | 0.30 |
| ▸ | CD274 | Q9NZQ7 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8873526 | 1.00 | PLG (0.34) | PLGHTR1DHTR1BHTR1AKMT2A | |
| SCHEMBL5170319 | 0.85 | KCNH2 (0.33) | HTR1DHTR1BHTR1AKMT2AHTR2A | |
| SCHEMBL2155869 | 0.85 | KCNH2 (0.33) | HTR1DHTR1BHTR1AKMT2AHTR2A | |
| SCHEMBL2155119 | 0.85 | IRAK4 (0.32) | HTR1DHTR1BHTR1AKMT2AHTR2A | |
| SCHEMBL24298899 | 0.85 | IRAK4 (0.32) | HTR1DHTR1BHTR1AKMT2AHTR2A | |
| SCHEMBL24324048 | 0.85 | KCNH2 (0.33) | HTR1DHTR1BHTR1AKMT2AHTR2A | |
| SCHEMBL5173514 | 0.85 | IRAK4 (0.32) | HTR1DHTR1BHTR1AKMT2AHTR2A | |
| SCHEMBL15905687 | 0.79 | HTR1D (0.32) | HTR1DHTR1BHTR1AKMT2AHTR2A | |
| SCHEMBL15905689 | 0.79 | HTR1D (0.32) | HTR1DHTR1BHTR1AKMT2AHTR2A | |
| SCHEMBL1438806 | 0.77 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7160907-B2 | Pleuromutilin derivatives | SMITHKLINE BEECHAM P.L.C. (GB) | 2007-01-09 | — | — | US | disclosed |
| US-7160907-B2 | Pleuromutilin derivatives | SMITHKLINE BEECHAM P.L.C. (GB) | 2007-01-09 | — | — | US | disclosed |
| US-5670652-A | REACTION OF NEOPENTYLGLYCINOL WITH CHLOROFORMIC ACID TO FORM ALKYLOXAZOLIDINONE | DEGUSSA AKTIENGESELLSCHAFT (DE) | 1997-09-23 | — | — | US | disclosed |