Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1I2 | O75469 | 1/20 | 0.37 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.37 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.37 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.36 |
| ▸ | HMGCR | P04035 | 1/20 | 0.36 |
| ▸ | RXRA | P19793 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8878123 | 0.86 | — | — | |
| SCHEMBL8878307 | 0.83 | PRKAA2 (0.39) | NR1I2NR4A2PDE4DPRKAA2HMGCR | |
| SCHEMBL8952891 | 0.81 | NR1I2 (0.42) | NR1I2NR4A2PDE4DPRKAA2HMGCR | |
| SCHEMBL8952880 | 0.81 | NR1I2 (0.42) | NR1I2NR4A2PDE4DPRKAA2HMGCR | |
| SCHEMBL8877543 | 0.79 | DHODH (0.37) | — | |
| SCHEMBL8876422 | 0.77 | GCGR (0.40) | — | |
| SCHEMBL8878327 | 0.76 | DHODH (0.51) | PRKAA2RXRA | |
| SCHEMBL8952869 | 0.75 | NR1I2 (0.42) | NR1I2NR4A2PDE4D | |
| SCHEMBL8877565 | 0.73 | NR1I2 (0.37) | NR1I2NR4A2PDE4DPRKAA2HMGCR | |
| SCHEMBL8879635 | 0.73 | HMGCR (0.39) | HMGCR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5691322-A | Quinoline and pyridine anchors for HMG-CoA reductase inhibitors | E.R. SQUIBB & SONS, INC. (US) | 1997-11-25 | — | — | US | disclosed |